Polyurethanes loaded with antibiotics: Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis

A. Piozzi, I. Francolini, L. Occhiaperti, R. Di Rosa, V. Ruggeri, G. Donelli

Research output: Contribution to journalArticle

Abstract

Acidic or basic polyurethanes were loaded with antibiotics to develop materials to prevent medical device-related infections. A correlation between polymer-antibiotic interactions and amount of drug absorbed by polymers and released over time was found. Since the employed antibiotics, i.e. amoxicillin, cefamandole nafate, rifampin and vancomycin, possessed at least an acidic group in their structural formula, the introduction of basic tertiary amines in the polyurethane side-chain resulted in an increased polymer ability to adsorb antibiotics. However, a stronger ionic interaction between this polymer and the antibiotics caused a release of lower amount of drug over time. Antibiotics released from polymers inhibited Staphylococcus epidermidis growth on agar. Antibiotic-loaded polyurethanes kept in water for increasing times were still able to show inhibition zones of bacterial growth. The antibacterial activity lasted up to 3 hours for amoxicillin, 24 hours for vancomycin, 8 days for cefamandole nafate and 8 months for rifampin.

Original languageEnglish
Pages (from-to)446-452
Number of pages7
JournalJournal of Chemotherapy
Volume16
Issue number5
Publication statusPublished - Oct 2004

Fingerprint

Polyurethanes
Staphylococcus epidermidis
Polymers
Anti-Bacterial Agents
Amoxicillin
Vancomycin
Rifampin
Growth
In Vitro Techniques
Drug Interactions
Agar
Amines
Equipment and Supplies
Water
Infection
Pharmaceutical Preparations

Keywords

  • Antibiotic
  • Biofilms
  • Catheter-related infections
  • Polyurethanes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

Cite this

Piozzi, A., Francolini, I., Occhiaperti, L., Di Rosa, R., Ruggeri, V., & Donelli, G. (2004). Polyurethanes loaded with antibiotics: Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis. Journal of Chemotherapy, 16(5), 446-452.

Polyurethanes loaded with antibiotics : Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis. / Piozzi, A.; Francolini, I.; Occhiaperti, L.; Di Rosa, R.; Ruggeri, V.; Donelli, G.

In: Journal of Chemotherapy, Vol. 16, No. 5, 10.2004, p. 446-452.

Research output: Contribution to journalArticle

Piozzi, A, Francolini, I, Occhiaperti, L, Di Rosa, R, Ruggeri, V & Donelli, G 2004, 'Polyurethanes loaded with antibiotics: Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis', Journal of Chemotherapy, vol. 16, no. 5, pp. 446-452.
Piozzi, A. ; Francolini, I. ; Occhiaperti, L. ; Di Rosa, R. ; Ruggeri, V. ; Donelli, G. / Polyurethanes loaded with antibiotics : Influence of polymer-antibiotic interactions on in vitro activity against Staphylococcus epidermidis. In: Journal of Chemotherapy. 2004 ; Vol. 16, No. 5. pp. 446-452.
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