Poor outcome of elderly patients with platinum-sensitive recurrent ovarian cancer

Results from the SOCRATES retrospective study

Sandro Pignata, Gabriella Ferrandina, Giovanna Scarfone, Paolo Scollo, Franco Odicino, Gennaro Cormio, Dionyssios Katsaros, Luigi Frigerio, Liliana Mereu, Fabio Ghezzi, Luigi Manzione, Rossella Lauria, Enrico Breda, Desiderio Gueli Alletti, Michela Ballardini, Alessandra Vernaglia, Roberto Sorio, Salvatore Tumolo, Pietro Musso, Giovanna Magni & 2 others Carmela Pisano, Alessandro Morabito

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Elderly patients with ovarian carcinoma have a poorer prognosis compared with their younger counterpart, and this depends in most cases on undertreatment. The aim of this study was to evaluate, retrospectively, the pattern of care and the prognosis of elderly patients with platinum-sensitive recurrent ovarian cancer. The SOCRATES study retrospectively assessed the pattern of care of a cohort of patients with recurrent platinum-sensitive ovarian cancer observed in the years 2000-2002 in 37 Italian centres. Data were collected between April and September 2005. Patients and methods: Patients with recurrent ovarian cancer with >6 months of platinum free interval were considered eligible. Four-hundred-ninety-three patient files were collected and 425 were considered eligible and analyzed. Ninety-four patients with age ≥70 years and 331 patients with age 1 vs. 1), performance status at recurrence (2-3 vs. 0-1), RFI (6-12 months vs. >12 months), age at recurrence, were independently associated with survival. Conclusion: Elderly patients with platinum-sensitive recurrent ovarian cancer receive less surgery and chemotherapy. Response to chemotherapy is better in younger patients. Age is an unfavourable factor independently associated to a worst prognosis.

Original languageEnglish
Pages (from-to)233-241
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume71
Issue number3
DOIs
Publication statusPublished - Sep 2009

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Platinum
Ovarian Neoplasms
Retrospective Studies
Recurrence
Drug Therapy
Carcinoma
Survival

Keywords

  • Chemotherapy
  • Elderly
  • Ovarian cancer
  • Recurrence

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Poor outcome of elderly patients with platinum-sensitive recurrent ovarian cancer : Results from the SOCRATES retrospective study. / Pignata, Sandro; Ferrandina, Gabriella; Scarfone, Giovanna; Scollo, Paolo; Odicino, Franco; Cormio, Gennaro; Katsaros, Dionyssios; Frigerio, Luigi; Mereu, Liliana; Ghezzi, Fabio; Manzione, Luigi; Lauria, Rossella; Breda, Enrico; Alletti, Desiderio Gueli; Ballardini, Michela; Vernaglia, Alessandra; Sorio, Roberto; Tumolo, Salvatore; Musso, Pietro; Magni, Giovanna; Pisano, Carmela; Morabito, Alessandro.

In: Critical Reviews in Oncology/Hematology, Vol. 71, No. 3, 09.2009, p. 233-241.

Research output: Contribution to journalArticle

Pignata, S, Ferrandina, G, Scarfone, G, Scollo, P, Odicino, F, Cormio, G, Katsaros, D, Frigerio, L, Mereu, L, Ghezzi, F, Manzione, L, Lauria, R, Breda, E, Alletti, DG, Ballardini, M, Vernaglia, A, Sorio, R, Tumolo, S, Musso, P, Magni, G, Pisano, C & Morabito, A 2009, 'Poor outcome of elderly patients with platinum-sensitive recurrent ovarian cancer: Results from the SOCRATES retrospective study', Critical Reviews in Oncology/Hematology, vol. 71, no. 3, pp. 233-241. https://doi.org/10.1016/j.critrevonc.2008.12.010
Pignata, Sandro ; Ferrandina, Gabriella ; Scarfone, Giovanna ; Scollo, Paolo ; Odicino, Franco ; Cormio, Gennaro ; Katsaros, Dionyssios ; Frigerio, Luigi ; Mereu, Liliana ; Ghezzi, Fabio ; Manzione, Luigi ; Lauria, Rossella ; Breda, Enrico ; Alletti, Desiderio Gueli ; Ballardini, Michela ; Vernaglia, Alessandra ; Sorio, Roberto ; Tumolo, Salvatore ; Musso, Pietro ; Magni, Giovanna ; Pisano, Carmela ; Morabito, Alessandro. / Poor outcome of elderly patients with platinum-sensitive recurrent ovarian cancer : Results from the SOCRATES retrospective study. In: Critical Reviews in Oncology/Hematology. 2009 ; Vol. 71, No. 3. pp. 233-241.
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abstract = "Background: Elderly patients with ovarian carcinoma have a poorer prognosis compared with their younger counterpart, and this depends in most cases on undertreatment. The aim of this study was to evaluate, retrospectively, the pattern of care and the prognosis of elderly patients with platinum-sensitive recurrent ovarian cancer. The SOCRATES study retrospectively assessed the pattern of care of a cohort of patients with recurrent platinum-sensitive ovarian cancer observed in the years 2000-2002 in 37 Italian centres. Data were collected between April and September 2005. Patients and methods: Patients with recurrent ovarian cancer with >6 months of platinum free interval were considered eligible. Four-hundred-ninety-three patient files were collected and 425 were considered eligible and analyzed. Ninety-four patients with age ≥70 years and 331 patients with age 1 vs. 1), performance status at recurrence (2-3 vs. 0-1), RFI (6-12 months vs. >12 months), age at recurrence, were independently associated with survival. Conclusion: Elderly patients with platinum-sensitive recurrent ovarian cancer receive less surgery and chemotherapy. Response to chemotherapy is better in younger patients. Age is an unfavourable factor independently associated to a worst prognosis.",
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AU - Pignata, Sandro

AU - Ferrandina, Gabriella

AU - Scarfone, Giovanna

AU - Scollo, Paolo

AU - Odicino, Franco

AU - Cormio, Gennaro

AU - Katsaros, Dionyssios

AU - Frigerio, Luigi

AU - Mereu, Liliana

AU - Ghezzi, Fabio

AU - Manzione, Luigi

AU - Lauria, Rossella

AU - Breda, Enrico

AU - Alletti, Desiderio Gueli

AU - Ballardini, Michela

AU - Vernaglia, Alessandra

AU - Sorio, Roberto

AU - Tumolo, Salvatore

AU - Musso, Pietro

AU - Magni, Giovanna

AU - Pisano, Carmela

AU - Morabito, Alessandro

PY - 2009/9

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N2 - Background: Elderly patients with ovarian carcinoma have a poorer prognosis compared with their younger counterpart, and this depends in most cases on undertreatment. The aim of this study was to evaluate, retrospectively, the pattern of care and the prognosis of elderly patients with platinum-sensitive recurrent ovarian cancer. The SOCRATES study retrospectively assessed the pattern of care of a cohort of patients with recurrent platinum-sensitive ovarian cancer observed in the years 2000-2002 in 37 Italian centres. Data were collected between April and September 2005. Patients and methods: Patients with recurrent ovarian cancer with >6 months of platinum free interval were considered eligible. Four-hundred-ninety-three patient files were collected and 425 were considered eligible and analyzed. Ninety-four patients with age ≥70 years and 331 patients with age 1 vs. 1), performance status at recurrence (2-3 vs. 0-1), RFI (6-12 months vs. >12 months), age at recurrence, were independently associated with survival. Conclusion: Elderly patients with platinum-sensitive recurrent ovarian cancer receive less surgery and chemotherapy. Response to chemotherapy is better in younger patients. Age is an unfavourable factor independently associated to a worst prognosis.

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