We have recently reported a series of 15 non-villous splenic marginal zone lymphoma patients, six of whom showed p53 mutations (40%). This molecular alteration did not correlate with any particular clinicopathologic feature at diagnosis. After a median follow-up of 56 months, four cases evolved into aggressive fatal non-Hodgkin's lymphoma (NHL) and two had refractory progressive disease; interestingly, p53 mutations were demonstrated in five of these patients at diagnosis. As the patients with wild-type p53 presented responsive or indolent disease, this genetic alteration may be an early marker of aggressive transformation or refractoriness, p53 evaluation at diagnosis could be advisable in this particular subset of NHL.
|Number of pages||4|
|Journal||British Journal of Haematology|
|Publication status||Published - 1997|
- Blastic transformation
- Non-villous splenic marginal zone lymphoma
- P53 mutations
ASJC Scopus subject areas