Poor prognosis in non-villous splenic marginal zone cell lymphoma is associated with p53 mutations

L. Baldini, A. Guffanti, L. Cro, N. S. Fracchiolla, M. Colombi, M. Motta, A. T. Maiolo, A. Neri

Research output: Contribution to journalArticlepeer-review

Abstract

We have recently reported a series of 15 non-villous splenic marginal zone lymphoma patients, six of whom showed p53 mutations (40%). This molecular alteration did not correlate with any particular clinicopathologic feature at diagnosis. After a median follow-up of 56 months, four cases evolved into aggressive fatal non-Hodgkin's lymphoma (NHL) and two had refractory progressive disease; interestingly, p53 mutations were demonstrated in five of these patients at diagnosis. As the patients with wild-type p53 presented responsive or indolent disease, this genetic alteration may be an early marker of aggressive transformation or refractoriness, p53 evaluation at diagnosis could be advisable in this particular subset of NHL.

Original languageEnglish
Pages (from-to)375-378
Number of pages4
JournalBritish Journal of Haematology
Volume99
Issue number2
Publication statusPublished - 1997

Keywords

  • Blastic transformation
  • Non-villous splenic marginal zone lymphoma
  • P53 mutations

ASJC Scopus subject areas

  • Hematology

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