Carcinoma scarsamente differenziato a ricca componente mioepiteliale della mammella: Aspetti morfologici, immunoistochimici ed espressione del gene mammaglobin

Translated title of the contribution: Poorly differentiate myoepithelial cell rich carcinoma of the breast: Morphological, immunohistochemistry and mammaglobin gene expression

Angelo G. Bonadio, P. Ferro, M. Moroni, N. Gorji, A. Giannico, P. Dessanti, F. Fais, B. Bacigalupo, S. Roncella, F. Fedeli

Research output: Contribution to journalArticle

Abstract

In this report, we describe a case of poorly differentiate myoepithelial cell rich carcinoma in with morphological findings of large poligonal nests with festoon-like pattern sometimes showing central necrosis, reminiscent of a comedo-like pattern and numerous mitoses. Immunohistochemical staining shows positive reaction for cytokeratin AE/1, CAM 5.2, 34βE12, vimentina, smooth muscle actin, EMA, S100 protein and oncogene cERB.b2 and negative for estrogen, progesteron, GFAP and cromogranin. Moreover, this carcinoma show the expression of the mammaglobin mRNA, a highly specific marker of breast epithelial cells that it is not expressed in all breast carcinoma.

Translated title of the contributionPoorly differentiate myoepithelial cell rich carcinoma of the breast: Morphological, immunohistochemistry and mammaglobin gene expression
Original languageItalian
Pages (from-to)209-213
Number of pages5
JournalPathologica
Volume95
Issue number4
Publication statusPublished - Aug 2003

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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  • Cite this

    Bonadio, A. G., Ferro, P., Moroni, M., Gorji, N., Giannico, A., Dessanti, P., Fais, F., Bacigalupo, B., Roncella, S., & Fedeli, F. (2003). Carcinoma scarsamente differenziato a ricca componente mioepiteliale della mammella: Aspetti morfologici, immunoistochimici ed espressione del gene mammaglobin. Pathologica, 95(4), 209-213.