Poorly differentiated ('insular') thyroid carcinoma. A reinterpretation of Langhans' 'wuchernde struma'

M. L. Carcangiu, G. Zampi, J. Rosai

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Abstract

Twenty-five cases of a distinctive type of thyroid carcinoma are presented. The key microscopic features are: formation of solid clusters ('insulae') of tumor cells containing a variable number of small follicles; small size and uniformity of the tumor cells; variable, but consistently present mitotic activity; capsular and blood vessel invasions and frequent necrotic foci, sometimes leading to the formation of 'peritheliomatous' structures. Metastases to regional lymph nodes, lung, and bones are common, and these often lead to the patient's death. We view this tumor as a poorly differentiated carcinoma, situated morphologically and biologically in an intermediate position between the well-differentiated (papillary and follicular) and the totally undifferentiated thyroid tumors. We believe that it is closely related, if not identical, to the tumor type described by Langhans in 1907 as 'wuchernde Struma'.

Original languageEnglish
Pages (from-to)655-668
Number of pages14
JournalAmerican Journal of Surgical Pathology
Volume8
Issue number9
Publication statusPublished - 1984

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Thyroid Neoplasms
Neoplasms
Blood Vessels
Thyroid Gland
Lymph Nodes
Neoplasm Metastasis
Carcinoma
Bone and Bones
Lung

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

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Poorly differentiated ('insular') thyroid carcinoma. A reinterpretation of Langhans' 'wuchernde struma'. / Carcangiu, M. L.; Zampi, G.; Rosai, J.

In: American Journal of Surgical Pathology, Vol. 8, No. 9, 1984, p. 655-668.

Research output: Contribution to journalArticle

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