Abstract
Parity, oral contraceptive (OC) use, age at menopause, a family history of the disease and selected aspects of diet have been related to the risk of ovarian cancer. The quantification of their impact on a population level may help focus and rank the importance of potential prevention strategies. Using data from a case-control study conducted in Italy between 1983 and 1991 on 971 ovarian cancer cases and 2758 control women we computed the multivariate relative risk estimates, and population attributable risks (PARs), i.e. the proportion of ovarian cancers that would have been avoided if a given exposure had not been present in the population. Overall, the PARs were 5% for nulliparity, 12% for never OC use and 4% for a family history of breast or ovarian cancer in first-degree relatives. Among women aged ≥50 years, later age at menopause accounted for 16% of all ovarian cancer cases. Low intake of green vegetables accounted for 24% of cases and a high fat score for 7%. All these factors together explained 51% of cases. In conclusion, even if the PAR estimates were based on several arbitrary assumptions, available knowledge could, in principle, explain over 50% of all ovarian cancer cases in this Italian population, thus indicating and quantifying the theoretical scope for prevention. (C) 2000 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 520-524 |
| Number of pages | 5 |
| Journal | European Journal of Cancer |
| Volume | 36 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Mar 2000 |
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Keywords
- Epidemiology
- Frequency
- Risk factors
- Urinary incontinence
- Women
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Population attributable risk for ovarian cancer. / Parazzini, F.; Chatenoud, L.; Chiantera, V.; Benzi, G.; Surace, M.; La Vecchia, C.
In: European Journal of Cancer, Vol. 36, No. 4, 03.2000, p. 520-524.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Population attributable risk for ovarian cancer
AU - Parazzini, F.
AU - Chatenoud, L.
AU - Chiantera, V.
AU - Benzi, G.
AU - Surace, M.
AU - La Vecchia, C.
PY - 2000/3
Y1 - 2000/3
N2 - Parity, oral contraceptive (OC) use, age at menopause, a family history of the disease and selected aspects of diet have been related to the risk of ovarian cancer. The quantification of their impact on a population level may help focus and rank the importance of potential prevention strategies. Using data from a case-control study conducted in Italy between 1983 and 1991 on 971 ovarian cancer cases and 2758 control women we computed the multivariate relative risk estimates, and population attributable risks (PARs), i.e. the proportion of ovarian cancers that would have been avoided if a given exposure had not been present in the population. Overall, the PARs were 5% for nulliparity, 12% for never OC use and 4% for a family history of breast or ovarian cancer in first-degree relatives. Among women aged ≥50 years, later age at menopause accounted for 16% of all ovarian cancer cases. Low intake of green vegetables accounted for 24% of cases and a high fat score for 7%. All these factors together explained 51% of cases. In conclusion, even if the PAR estimates were based on several arbitrary assumptions, available knowledge could, in principle, explain over 50% of all ovarian cancer cases in this Italian population, thus indicating and quantifying the theoretical scope for prevention. (C) 2000 Elsevier Science Ltd.
AB - Parity, oral contraceptive (OC) use, age at menopause, a family history of the disease and selected aspects of diet have been related to the risk of ovarian cancer. The quantification of their impact on a population level may help focus and rank the importance of potential prevention strategies. Using data from a case-control study conducted in Italy between 1983 and 1991 on 971 ovarian cancer cases and 2758 control women we computed the multivariate relative risk estimates, and population attributable risks (PARs), i.e. the proportion of ovarian cancers that would have been avoided if a given exposure had not been present in the population. Overall, the PARs were 5% for nulliparity, 12% for never OC use and 4% for a family history of breast or ovarian cancer in first-degree relatives. Among women aged ≥50 years, later age at menopause accounted for 16% of all ovarian cancer cases. Low intake of green vegetables accounted for 24% of cases and a high fat score for 7%. All these factors together explained 51% of cases. In conclusion, even if the PAR estimates were based on several arbitrary assumptions, available knowledge could, in principle, explain over 50% of all ovarian cancer cases in this Italian population, thus indicating and quantifying the theoretical scope for prevention. (C) 2000 Elsevier Science Ltd.
KW - Epidemiology
KW - Frequency
KW - Risk factors
KW - Urinary incontinence
KW - Women
UR - http://www.scopus.com/inward/record.url?scp=0034094636&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0034094636&partnerID=8YFLogxK
U2 - 10.1016/S0959-8049(99)00313-5
DO - 10.1016/S0959-8049(99)00313-5
M3 - Article
C2 - 10717530
AN - SCOPUS:0034094636
VL - 36
SP - 520
EP - 524
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 4
ER -