Population-based mapping of pulmonary adenoma susceptibility 1 locus

T. A. Dragani, S. Hirohashi, T. Juji, K. Kawajiri, M. Kihara, M. Ono-Kihara, G. Manenti, T. Nomoto, H. Sugimura, K. Genka, J. Yokota, T. Takahashi, T. Mitsudomi, M. Nagao

Research output: Contribution to journalArticle

Abstract

Pulmonary adenoma susceptibility 1 (Pas1), the major locus affecting inherited predisposition to lung tumor development in mice, maps near the Kras2 gene. We previously reported a significant association between a KRAS2/RsaI polymorphism and the risk and prognosis of lung adenocarcinoma (ADCA) in the Italian population. In the present case-control study, we examined 269 lung ADCA patients, 121 squamous cell lung carcinoma patients, and 632 healthy individuals (general population controls) in the Japanese population with genetic markers spanning ~1200 kb in the KRAS2 region. Allele-specific oligonucleotide hybridization revealed the same KRAS2/RsaI polymorphism associated with risk and prognosis as in Italian lung ADCA patients; the polymorphism was significantly associated with clinical stage (P 0.001) and survival rate (log rank = 0.0014), confirming the mapping of PAS1 and pointing to the role of this locus in human lung cancer.

Original languageEnglish
Pages (from-to)5017-5020
Number of pages4
JournalCancer Research
Volume60
Issue number18
Publication statusPublished - Sep 15 2000

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Dragani, T. A., Hirohashi, S., Juji, T., Kawajiri, K., Kihara, M., Ono-Kihara, M., Manenti, G., Nomoto, T., Sugimura, H., Genka, K., Yokota, J., Takahashi, T., Mitsudomi, T., & Nagao, M. (2000). Population-based mapping of pulmonary adenoma susceptibility 1 locus. Cancer Research, 60(18), 5017-5020.