TY - JOUR
T1 - Population differences in allele frequencies at the OLR1 locus may suggest geographic disparities in cardiovascular risk events
AU - Predazzi, Irene M.
AU - Martínez-Labarga, Cristina
AU - Vecchione, Lucia
AU - Mango, Ruggiero
AU - Ciccacci, Cinzia
AU - Amati, Francesca
AU - Ottoni, Claudio
AU - Crawford, Michael H.
AU - Rickards, Olga
AU - Romeo, Francesco
AU - Novelli, Giuseppe
PY - 2010/4/28
Y1 - 2010/4/28
N2 - Background: Several studies have demonstrated a link between cardiovascular disease (CVD) susceptibility and the genetic background of populations. Endothelial activation and dysfunction induced by oxidized low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. The oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1) gene is the main receptor of ox-LDL. We have previously characterized two polymorphisms (rs3736235 and rs11053646) associated with the risk for coronary artery disease (CAD) and acute myocardial infarction (AMI). Aim: Given their clinical significance, it is of interest to know the distribution of these variants in populations from different continents. Subjects and methods: A total of 1229 individuals from 17 different African, Asian and European populations was genotyped for the two considered markers. Results: The high frequencies of ancestral alleles in South-Saharan populations is concordant with the African origin of our species. The results highlight that African populations are closer to Asians, and clearly separated from the Europeans. Conclusion: The results confirm significant genetic structuring among populations and suggest a possible basis for varying susceptibility to CVD among groups correlated with the geographical location of populations linked with the migrations out of Africa, or with different lifestyle.
AB - Background: Several studies have demonstrated a link between cardiovascular disease (CVD) susceptibility and the genetic background of populations. Endothelial activation and dysfunction induced by oxidized low-density lipoprotein (ox-LDL) is one of the key steps in the initiation of atherosclerosis. The oxidized low density lipoprotein (lectin-like) receptor 1 (OLR1) gene is the main receptor of ox-LDL. We have previously characterized two polymorphisms (rs3736235 and rs11053646) associated with the risk for coronary artery disease (CAD) and acute myocardial infarction (AMI). Aim: Given their clinical significance, it is of interest to know the distribution of these variants in populations from different continents. Subjects and methods: A total of 1229 individuals from 17 different African, Asian and European populations was genotyped for the two considered markers. Results: The high frequencies of ancestral alleles in South-Saharan populations is concordant with the African origin of our species. The results highlight that African populations are closer to Asians, and clearly separated from the Europeans. Conclusion: The results confirm significant genetic structuring among populations and suggest a possible basis for varying susceptibility to CVD among groups correlated with the geographical location of populations linked with the migrations out of Africa, or with different lifestyle.
KW - Cardiovascular disease
KW - OLR1
KW - Single nucleotide polymorphisms
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U2 - 10.3109/03014460903393857
DO - 10.3109/03014460903393857
M3 - Article
C2 - 19961348
AN - SCOPUS:77949304181
VL - 37
SP - 136
EP - 148
JO - Annals of Human Biology
JF - Annals of Human Biology
SN - 0301-4460
IS - 2
ER -