Population immunology: Germs, aging and inflammation

Ana Maria C Faria, Claudio Franceschi

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.

Original languageEnglish
Title of host publicationEco-immunology: Evolutive Aspects and Future Perspectives
PublisherSpringer Netherlands
Pages145-161
Number of pages17
ISBN (Print)9789401787123, 9401787115, 9789401787116
DOIs
Publication statusPublished - Jan 1 2014

Fingerprint

Allergy and Immunology
Inflammation
Immunity
Biomarkers
Population
Infection
Communicable Diseases
Immune System
Chronic Disease
Immunosenescence

Keywords

  • Aging
  • Genetics
  • Infection
  • Inflammation
  • Microbiota

ASJC Scopus subject areas

  • Medicine(all)
  • Immunology and Microbiology(all)

Cite this

Faria, A. M. C., & Franceschi, C. (2014). Population immunology: Germs, aging and inflammation. In Eco-immunology: Evolutive Aspects and Future Perspectives (pp. 145-161). Springer Netherlands. https://doi.org/10.1007/978-94-017-8712-3_8

Population immunology : Germs, aging and inflammation. / Faria, Ana Maria C; Franceschi, Claudio.

Eco-immunology: Evolutive Aspects and Future Perspectives. Springer Netherlands, 2014. p. 145-161.

Research output: Chapter in Book/Report/Conference proceedingChapter

Faria, AMC & Franceschi, C 2014, Population immunology: Germs, aging and inflammation. in Eco-immunology: Evolutive Aspects and Future Perspectives. Springer Netherlands, pp. 145-161. https://doi.org/10.1007/978-94-017-8712-3_8
Faria AMC, Franceschi C. Population immunology: Germs, aging and inflammation. In Eco-immunology: Evolutive Aspects and Future Perspectives. Springer Netherlands. 2014. p. 145-161 https://doi.org/10.1007/978-94-017-8712-3_8
Faria, Ana Maria C ; Franceschi, Claudio. / Population immunology : Germs, aging and inflammation. Eco-immunology: Evolutive Aspects and Future Perspectives. Springer Netherlands, 2014. pp. 145-161
@inbook{7cf872c70059445796c75d62a861d7a2,
title = "Population immunology: Germs, aging and inflammation",
abstract = "Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.",
keywords = "Aging, Genetics, Infection, Inflammation, Microbiota",
author = "Faria, {Ana Maria C} and Claudio Franceschi",
year = "2014",
month = "1",
day = "1",
doi = "10.1007/978-94-017-8712-3_8",
language = "English",
isbn = "9789401787123",
pages = "145--161",
booktitle = "Eco-immunology: Evolutive Aspects and Future Perspectives",
publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Population immunology

T2 - Germs, aging and inflammation

AU - Faria, Ana Maria C

AU - Franceschi, Claudio

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.

AB - Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.

KW - Aging

KW - Genetics

KW - Infection

KW - Inflammation

KW - Microbiota

UR - http://www.scopus.com/inward/record.url?scp=84931431197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931431197&partnerID=8YFLogxK

U2 - 10.1007/978-94-017-8712-3_8

DO - 10.1007/978-94-017-8712-3_8

M3 - Chapter

AN - SCOPUS:84931431197

SN - 9789401787123

SN - 9401787115

SN - 9789401787116

SP - 145

EP - 161

BT - Eco-immunology: Evolutive Aspects and Future Perspectives

PB - Springer Netherlands

ER -