Abstract
Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.
| Original language | English |
|---|---|
| Title of host publication | Eco-immunology: Evolutive Aspects and Future Perspectives |
| Publisher | Springer Netherlands |
| Pages | 145-161 |
| Number of pages | 17 |
| ISBN (Print) | 9789401787123, 9401787115, 9789401787116 |
| DOIs | |
| Publication status | Published - Jan 1 2014 |
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Keywords
- Aging
- Genetics
- Infection
- Inflammation
- Microbiota
ASJC Scopus subject areas
- Medicine(all)
- Immunology and Microbiology(all)
Cite this
Population immunology : Germs, aging and inflammation. / Faria, Ana Maria C; Franceschi, Claudio.
Eco-immunology: Evolutive Aspects and Future Perspectives. Springer Netherlands, 2014. p. 145-161.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Population immunology
T2 - Germs, aging and inflammation
AU - Faria, Ana Maria C
AU - Franceschi, Claudio
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.
AB - Immunosenescence has been described as a combination of dysfunctional immunity with a state of low grade chronic inflammation (inflammaging) in the elderly. These processes may result either in increased susceptibility to infections or in the development of chronic inflammatory diseases and frailty in the elderly. However, not all elderly bear a dysfunctional immunity. Senescence may also be accompanied by a remodeling of the immune system that is associated with increased longevity and healthy aging. The concept of healthy aging has been proposed initially in Europe to describe the individuals who reach advanced age free of inflammatory consequences of immunosenescence. Since then, the quest for biological markers of healthy aging has been focused on the consequences of inflammaging, but this inflammatory status might be a deleterious event restricted to populations living in clean environments. In other parts of the world where infectious diseases are still prevalent, inflammatory responses may be beneficial and needed to cope with infections agents. Therefore, the debate over the biological markers of healthy aging would have to take into account geographical, cultural and environmental differences that reflect the changes in the past century in our contacts with microorganisms and their immunological consequences.
KW - Aging
KW - Genetics
KW - Infection
KW - Inflammation
KW - Microbiota
UR - http://www.scopus.com/inward/record.url?scp=84931431197&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84931431197&partnerID=8YFLogxK
U2 - 10.1007/978-94-017-8712-3_8
DO - 10.1007/978-94-017-8712-3_8
M3 - Chapter
AN - SCOPUS:84931431197
SN - 9789401787123
SN - 9401787115
SN - 9789401787116
SP - 145
EP - 161
BT - Eco-immunology: Evolutive Aspects and Future Perspectives
PB - Springer Netherlands
ER -