TY - JOUR
T1 - Population-specific association of genes for telomere-associated proteins with longevity in an Italian population
AU - Crocco, Paolina
AU - Barale, Roberto
AU - Rose, Giuseppina
AU - Rizzato, Cosmeri
AU - Santoro, Aurelia
AU - De Rango, Francesco
AU - Carrai, Maura
AU - Fogar, Paola
AU - Monti, Daniela
AU - Biondi, Fiammetta
AU - Bucci, Laura
AU - Ostan, Rita
AU - Tallaro, Federica
AU - Montesanto, Alberto
AU - Zambon, Carlo Federico
AU - Franceschi, Claudio
AU - Canzian, Federico
AU - Passarino, Giuseppe
AU - Campa, Daniele
PY - 2015/6/15
Y1 - 2015/6/15
N2 - Leukocyte telomere length (LTL) has been observed to be hereditable and correlated with longevity. However, contrasting results have been reported in different populations on the value of LTL heritability and on how biology of telomeres influences longevity. We investigated whether the variability of genes correlated to telomere maintenance is associated with telomere length and affects longevity in a population from Southern Italy (20–106 years). For this purpose we analyzed thirty-one polymorphisms in eight telomerase-associated genes of which twelve in the genes coding for the core enzyme (TERT and TERC) and the remaining in genes coding for components of the telomerase complex (TERF1, TERF2, TERF2IP, TNKS, TNKS2 and TEP1). We did not observe (after correcting for multiple testing) statistically significant associations between SNPs and LTL, possibly suggesting a low genetic influence of the variability of these genes on LTL in the elderly. On the other hand, we found that the variability of genes encoding for TERF1 and TNKS2, not directly involved in LTL, but important for keeping the integrity of the structure, shows a significant association with longevity. This suggests that the maintenance of these chromosomal structures may be critically important for preventing, or delaying, senescence and aging. Such a correlation was not observed in a population from northern Italy that we used as an independent replication set. This discrepancy is in line with previous reports regarding both the population specificity of results on telomere biology and the differences of aging in northern and southern Italy.
AB - Leukocyte telomere length (LTL) has been observed to be hereditable and correlated with longevity. However, contrasting results have been reported in different populations on the value of LTL heritability and on how biology of telomeres influences longevity. We investigated whether the variability of genes correlated to telomere maintenance is associated with telomere length and affects longevity in a population from Southern Italy (20–106 years). For this purpose we analyzed thirty-one polymorphisms in eight telomerase-associated genes of which twelve in the genes coding for the core enzyme (TERT and TERC) and the remaining in genes coding for components of the telomerase complex (TERF1, TERF2, TERF2IP, TNKS, TNKS2 and TEP1). We did not observe (after correcting for multiple testing) statistically significant associations between SNPs and LTL, possibly suggesting a low genetic influence of the variability of these genes on LTL in the elderly. On the other hand, we found that the variability of genes encoding for TERF1 and TNKS2, not directly involved in LTL, but important for keeping the integrity of the structure, shows a significant association with longevity. This suggests that the maintenance of these chromosomal structures may be critically important for preventing, or delaying, senescence and aging. Such a correlation was not observed in a population from northern Italy that we used as an independent replication set. This discrepancy is in line with previous reports regarding both the population specificity of results on telomere biology and the differences of aging in northern and southern Italy.
KW - Aging
KW - Gene variability
KW - Telomerase
KW - Telomere
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U2 - 10.1007/s10522-015-9551-6
DO - 10.1007/s10522-015-9551-6
M3 - Article
C2 - 25631672
AN - SCOPUS:84939416280
VL - 16
SP - 353
EP - 364
JO - Biogerontology
JF - Biogerontology
SN - 1389-5729
IS - 3
ER -