Porcine orthotopic liver autotransplantation: Facilitated technique

S. Gruttadauria, G. Marino, F. Catalano, A. V. Sgroi, G. L. Di Mauro, F. Basile

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The technique of a liver autograft in the pig has three advantages: (1) It provides an excellent training model of liver transplantation, (2) it provides an experimental model for cancer research, and (3) it is more economical than liver allotransplant. We describe a facilitated technique of liver autograft, which can be employed to develop experimental models without the use of a biopump. Mean blood arterial pressure, heart rate, pH, and lactates were tested during the liver grafting and at the end of the procedure in pigs that underwent autografting of the liver and compared with pigs that underwent an orthotopic liver allotransplantation. The cell damage was assessed in the same two groups of animals by monitoring aspartate aminotransferase (AST) and alanine aminotransferase (ALT) blood levels and with the MEGX test, 15 min after the beginning of reperfusion. The surgical procedure may be divided into three parts: hepatectomy, side-to-side portocaval shunt with passive caval-jugular shunt, and reimplantation. This procedure could have a clinical indication for otherwise unresectable liver tumors.

Original languageEnglish
Pages (from-to)79-82
Number of pages4
JournalJournal of Investigative Surgery
Volume14
Issue number2
DOIs
Publication statusPublished - 2001

Fingerprint

Autologous Transplantation
Swine
Liver
Autografts
monoethylglycinexylidide
Liver Transplantation
Lactates
Theoretical Models
Venae Cavae
Replantation
Hepatectomy
Aspartate Aminotransferases
Alanine Transaminase
Reperfusion
Neoplasms
Arterial Pressure
Neck
Heart Rate
Blood Pressure
Research

Keywords

  • Experimental surgery
  • Liver surgery
  • Porcine orthotopic liver autograft

ASJC Scopus subject areas

  • Surgery

Cite this

Porcine orthotopic liver autotransplantation : Facilitated technique. / Gruttadauria, S.; Marino, G.; Catalano, F.; Sgroi, A. V.; Di Mauro, G. L.; Basile, F.

In: Journal of Investigative Surgery, Vol. 14, No. 2, 2001, p. 79-82.

Research output: Contribution to journalArticle

Gruttadauria, S. ; Marino, G. ; Catalano, F. ; Sgroi, A. V. ; Di Mauro, G. L. ; Basile, F. / Porcine orthotopic liver autotransplantation : Facilitated technique. In: Journal of Investigative Surgery. 2001 ; Vol. 14, No. 2. pp. 79-82.
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