Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari; Davide Canton; Nadia Zaffaroni; Raffaella Villa; Massimo Tormen; Enzo di Fabrizio

doi:10.1016/j.mee.2006.01.113

Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari, Davide Canton, Nadia Zaffaroni, Raffaella Villa, Massimo Tormen, Enzo di Fabrizio

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

Original language	English
Pages (from-to)	1598-1601
Number of pages	4
Journal	Microelectronic Engineering
Volume	83
Issue number	4-9 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mee.2006.01.113
Publication status	Published - Apr 2006

Keywords

Controlled Drug Delivery
Doxorubicin
Porous Silicon
Post-surgical Chemotherapy

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Atomic and Molecular Physics, and Optics

Access to Document

10.1016/j.mee.2006.01.113

Cite this

@article{ba5cd972d7a44d2998585f9f732d0b3f,

title = "Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent",

abstract = "One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.",

keywords = "Controlled Drug Delivery, Doxorubicin, Porous Silicon, Post-surgical Chemotherapy",

author = "Lisa Vaccari and Davide Canton and Nadia Zaffaroni and Raffaella Villa and Massimo Tormen and {di Fabrizio}, Enzo",

year = "2006",

month = apr,

doi = "10.1016/j.mee.2006.01.113",

language = "English",

volume = "83",

pages = "1598--1601",

journal = "Microelectronic Engineering",

issn = "0167-9317",

publisher = "Elsevier",

number = "4-9 SPEC. ISS.",

}

TY - JOUR

T1 - Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

AU - Vaccari, Lisa

AU - Canton, Davide

AU - Zaffaroni, Nadia

AU - Villa, Raffaella

AU - Tormen, Massimo

AU - di Fabrizio, Enzo

PY - 2006/4

Y1 - 2006/4

N2 - One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

AB - One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

KW - Controlled Drug Delivery

KW - Doxorubicin

KW - Porous Silicon

KW - Post-surgical Chemotherapy

UR - http://www.scopus.com/inward/record.url?scp=33646057408&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646057408&partnerID=8YFLogxK

U2 - 10.1016/j.mee.2006.01.113

DO - 10.1016/j.mee.2006.01.113

M3 - Article

AN - SCOPUS:33646057408

VL - 83

SP - 1598

EP - 1601

JO - Microelectronic Engineering

JF - Microelectronic Engineering

SN - 0167-9317

IS - 4-9 SPEC. ISS.

ER -

Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this