Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari; Davide Canton; Nadia Zaffaroni; Raffaella Villa; Massimo Tormen; Enzo di Fabrizio

doi:10.1016/j.mee.2006.01.113

Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari, Davide Canton, Nadia Zaffaroni, Raffaella Villa, Massimo Tormen, Enzo di Fabrizio

Fondazione IRCCS Istituto Nazionale dei Tumori

Research output: Contribution to journal › Article › peer-review

Abstract

One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

Original language	English
Pages (from-to)	1598-1601
Number of pages	4
Journal	Microelectronic Engineering
Volume	83
Issue number	4-9 SPEC. ISS.
DOIs	https://doi.org/10.1016/j.mee.2006.01.113
Publication status	Published - Apr 2006

Keywords

Controlled Drug Delivery
Doxorubicin
Porous Silicon
Post-surgical Chemotherapy

ASJC Scopus subject areas

Hardware and Architecture
Electrical and Electronic Engineering
Electronic, Optical and Magnetic Materials
Surfaces, Coatings and Films
Atomic and Molecular Physics, and Optics

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AU - Tormen, Massimo

AU - di Fabrizio, Enzo

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KW - Porous Silicon

KW - Post-surgical Chemotherapy

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