Porous silicon as drug carrier for controlled delivery of doxorubicin anticancer agent

Lisa Vaccari, Davide Canton, Nadia Zaffaroni, Raffaella Villa, Massimo Tormen, Enzo di Fabrizio

Research output: Contribution to journalArticlepeer-review

Abstract

One of the topics of the biomedical research is to design and develop new drug delivery systems able to perform time-controlled release of medicals with target specificity. Porous silicon, characterized by macropores of 2 μm average diameter, with a 200 nm thick nanoporous coverage, was produced and its potential applications as drug-carrier were investigated. Doxorubicin loaded porous silicon bits exhibited a time-depending drug delivery profile that is in trend with the cytotoxicity of adenocarcinoma cancer cells exposed to bits.

Original languageEnglish
Pages (from-to)1598-1601
Number of pages4
JournalMicroelectronic Engineering
Volume83
Issue number4-9 SPEC. ISS.
DOIs
Publication statusPublished - Apr 2006

Keywords

  • Controlled Drug Delivery
  • Doxorubicin
  • Porous Silicon
  • Post-surgical Chemotherapy

ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Atomic and Molecular Physics, and Optics

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