Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer

Massimiliano Bissolati, Maria Teresa Sandri, Giovanni Burtulo, Laura Zorzino, Gianpaolo Balzano, Marco Braga

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Pancreatic cancer patients underwent surgical resection often present distant metastases early after surgery. Detection of circulating tumor cells (CTCs) has been correlated to a worse oncological outcome in patients with advanced pancreatic cancer. The objective of this pilot study is to investigate the possible prognostic role of CTCs in patients undergoing surgery for pancreatic cancer. In 20 patients undergoing pancreatic resection, 10 mL blood sample was collected intraoperatively from both systemic circulation (SC) and portal vein (PV). Blood sample was analyzed for CTCs with CellSearch® system. All patients underwent an oncologic follow-up for at least 3 years, quarterly. CTCs were detected in nine (45 %) patients: five patients had CTCs in PV only, three patients in both SC and PV, and one patient in SC only. CTC-positive and CTC-negative patients were similar for demographics and cancer stage pattern. No significant differences were found in both overall and disease-free survival between CTC-positive and CTC-negative patients. At 3-year follow-up, portal vein CTC-positive patients presented a higher rate of liver metastases than CTC-negative patients (53 vs. 8 %, p = 0.038). CTCs were found in 45 % of the patients. No correlation between CTCs and survival was found. The presence of CTCs in portal vein has been associated to higher rate of liver metastases after surgery.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalTumor Biology
Volume36
Issue number2
DOIs
Publication statusPublished - 2015

Fingerprint

Circulating Neoplastic Cells
Portal Vein
Pancreatic Neoplasms
Neoplasm Metastasis
Liver

Keywords

  • Circulating tumor cells
  • Liver metastases
  • Pancreatic cancer
  • Portal vein
  • Surgery

ASJC Scopus subject areas

  • Cancer Research
  • Medicine(all)

Cite this

Portal vein-circulating tumor cells predict liver metastases in patients with resectable pancreatic cancer. / Bissolati, Massimiliano; Sandri, Maria Teresa; Burtulo, Giovanni; Zorzino, Laura; Balzano, Gianpaolo; Braga, Marco.

In: Tumor Biology, Vol. 36, No. 2, 2015, p. 991-996.

Research output: Contribution to journalArticle

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abstract = "Pancreatic cancer patients underwent surgical resection often present distant metastases early after surgery. Detection of circulating tumor cells (CTCs) has been correlated to a worse oncological outcome in patients with advanced pancreatic cancer. The objective of this pilot study is to investigate the possible prognostic role of CTCs in patients undergoing surgery for pancreatic cancer. In 20 patients undergoing pancreatic resection, 10 mL blood sample was collected intraoperatively from both systemic circulation (SC) and portal vein (PV). Blood sample was analyzed for CTCs with CellSearch{\circledR} system. All patients underwent an oncologic follow-up for at least 3 years, quarterly. CTCs were detected in nine (45 {\%}) patients: five patients had CTCs in PV only, three patients in both SC and PV, and one patient in SC only. CTC-positive and CTC-negative patients were similar for demographics and cancer stage pattern. No significant differences were found in both overall and disease-free survival between CTC-positive and CTC-negative patients. At 3-year follow-up, portal vein CTC-positive patients presented a higher rate of liver metastases than CTC-negative patients (53 vs. 8 {\%}, p = 0.038). CTCs were found in 45 {\%} of the patients. No correlation between CTCs and survival was found. The presence of CTCs in portal vein has been associated to higher rate of liver metastases after surgery.",
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AU - Balzano, Gianpaolo

AU - Braga, Marco

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