Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases

Lorenzo Capussotti, Andrea Muratore, Filippo Baracchi, Bernard Lelong, Alessandro Ferrero, Daniele Regge, Jean Robert Delpero

Research output: Contribution to journalArticle

Abstract

Objective: To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE). The small size of the remnant liver and chemotherapy-induced liver injury increase the risk of postoperative hepatic insufficiency after major hepatic resection for colorectal liver metastases. Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and Patients: We retrospectively reviewed 48 patients with colorectal liver metastases who underwent PVL (n = 17) or PVE (n = 31) at the Istituto per la Ricerca e la Cura del Cancro or the Institut Paoli-Calmette from March 1, 2000, through August 31, 2006. Main Outcome Measures: To compare the volume increase of segments 2 and 3, segment 4, and of the caudate lobe in patients who have undergone PVL or PVE in preparation for a major hepatic resection. Results: There were no deaths related to PVE or PVL. Portal vein ligation was associated with resection of synchronous colorectal cancer in 16 patients. Resection of a liver metastasis in the remnant liver was performed in 11 patients. The median estimated baseline volume of segments 2 and 3 was 17.7% in the PVL group and 17.5% in the PVE group (P = .72). After PVL or PVE, it increased to 26.9% and 24.7%, respectively (P = .95), for volumetric increases of 43.1% and 53.4%, respectively (P = .39). The volumetric increases of segment 4 and the caudate lobe were similar. Conclusion: Portal vein ligation is as effective as PVE in inducing hypertrophy of the remnant liver volume.

Original languageEnglish
Pages (from-to)978-982
Number of pages5
JournalArchives of Surgery
Volume143
Issue number10
DOIs
Publication statusPublished - Oct 2008

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Portal Vein
Ligation
Neoplasm Metastasis
Liver
Therapeutics
Hypertrophy
Hepatic Insufficiency
Colorectal Neoplasms

ASJC Scopus subject areas

  • Surgery

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Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases. / Capussotti, Lorenzo; Muratore, Andrea; Baracchi, Filippo; Lelong, Bernard; Ferrero, Alessandro; Regge, Daniele; Delpero, Jean Robert.

In: Archives of Surgery, Vol. 143, No. 10, 10.2008, p. 978-982.

Research output: Contribution to journalArticle

Capussotti, Lorenzo ; Muratore, Andrea ; Baracchi, Filippo ; Lelong, Bernard ; Ferrero, Alessandro ; Regge, Daniele ; Delpero, Jean Robert. / Portal vein ligation as an efficient method of increasing the future liver remnant volume in the surgical treatment of colorectal metastases. In: Archives of Surgery. 2008 ; Vol. 143, No. 10. pp. 978-982.
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abstract = "Objective: To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE). The small size of the remnant liver and chemotherapy-induced liver injury increase the risk of postoperative hepatic insufficiency after major hepatic resection for colorectal liver metastases. Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and Patients: We retrospectively reviewed 48 patients with colorectal liver metastases who underwent PVL (n = 17) or PVE (n = 31) at the Istituto per la Ricerca e la Cura del Cancro or the Institut Paoli-Calmette from March 1, 2000, through August 31, 2006. Main Outcome Measures: To compare the volume increase of segments 2 and 3, segment 4, and of the caudate lobe in patients who have undergone PVL or PVE in preparation for a major hepatic resection. Results: There were no deaths related to PVE or PVL. Portal vein ligation was associated with resection of synchronous colorectal cancer in 16 patients. Resection of a liver metastasis in the remnant liver was performed in 11 patients. The median estimated baseline volume of segments 2 and 3 was 17.7{\%} in the PVL group and 17.5{\%} in the PVE group (P = .72). After PVL or PVE, it increased to 26.9{\%} and 24.7{\%}, respectively (P = .95), for volumetric increases of 43.1{\%} and 53.4{\%}, respectively (P = .39). The volumetric increases of segment 4 and the caudate lobe were similar. Conclusion: Portal vein ligation is as effective as PVE in inducing hypertrophy of the remnant liver volume.",
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AU - Regge, Daniele

AU - Delpero, Jean Robert

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N2 - Objective: To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE). The small size of the remnant liver and chemotherapy-induced liver injury increase the risk of postoperative hepatic insufficiency after major hepatic resection for colorectal liver metastases. Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and Patients: We retrospectively reviewed 48 patients with colorectal liver metastases who underwent PVL (n = 17) or PVE (n = 31) at the Istituto per la Ricerca e la Cura del Cancro or the Institut Paoli-Calmette from March 1, 2000, through August 31, 2006. Main Outcome Measures: To compare the volume increase of segments 2 and 3, segment 4, and of the caudate lobe in patients who have undergone PVL or PVE in preparation for a major hepatic resection. Results: There were no deaths related to PVE or PVL. Portal vein ligation was associated with resection of synchronous colorectal cancer in 16 patients. Resection of a liver metastasis in the remnant liver was performed in 11 patients. The median estimated baseline volume of segments 2 and 3 was 17.7% in the PVL group and 17.5% in the PVE group (P = .72). After PVL or PVE, it increased to 26.9% and 24.7%, respectively (P = .95), for volumetric increases of 43.1% and 53.4%, respectively (P = .39). The volumetric increases of segment 4 and the caudate lobe were similar. Conclusion: Portal vein ligation is as effective as PVE in inducing hypertrophy of the remnant liver volume.

AB - Objective: To compare the volumetric increase of segments 2 and 3, segment 4, and the caudate lobe after portal vein ligation (PVL) and portal vein embolization (PVE). The small size of the remnant liver and chemotherapy-induced liver injury increase the risk of postoperative hepatic insufficiency after major hepatic resection for colorectal liver metastases. Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and Patients: We retrospectively reviewed 48 patients with colorectal liver metastases who underwent PVL (n = 17) or PVE (n = 31) at the Istituto per la Ricerca e la Cura del Cancro or the Institut Paoli-Calmette from March 1, 2000, through August 31, 2006. Main Outcome Measures: To compare the volume increase of segments 2 and 3, segment 4, and of the caudate lobe in patients who have undergone PVL or PVE in preparation for a major hepatic resection. Results: There were no deaths related to PVE or PVL. Portal vein ligation was associated with resection of synchronous colorectal cancer in 16 patients. Resection of a liver metastasis in the remnant liver was performed in 11 patients. The median estimated baseline volume of segments 2 and 3 was 17.7% in the PVL group and 17.5% in the PVE group (P = .72). After PVL or PVE, it increased to 26.9% and 24.7%, respectively (P = .95), for volumetric increases of 43.1% and 53.4%, respectively (P = .39). The volumetric increases of segment 4 and the caudate lobe were similar. Conclusion: Portal vein ligation is as effective as PVE in inducing hypertrophy of the remnant liver volume.

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