Portal Vein Thrombosis and Markers of Inflammation in Hepatocellular Carcinoma

B. I. Carr, V. Guerra, R. Donghia

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Macroscopic portal vein thrombosis (PVT) is a major poor prognosis factor in patients with hepatocellular carcinoma (HCC). Inflammation is increasingly recognized to be part of the hepatocarcinogenic process and its markers are also prognostically useful. Aims: To examine the relationship of inflammation biomarkers to the presence of PVT and to survival in PVT patients with HCC. Methods: A large HCC cohort was examined for the presence of PVT and analyzed retrospectively. Results: Blood levels of NLR, PLR, ESR, CRP, AFP and GGTP were significantly related to the presence of PVT, but not the Glasgow Index. For patients with low alpha-fetoprotein levels, blood ESR and GGTP levels were also significantly increased in patients with PVT compared with those in patients without PVT. In a Cox regression model, serum GGTP levels had a significantly increased hazard ratio on death (1.52, p = 0.008). Kaplan-Meier analysis showed that PVT patients with low serum GGTP levels had significantly longer survival than PVT patients with high GGTP levels (p = 0.0041). Conclusions: Indices of inflammation, especially serum GGTP levels, related significantly to the presence of PVT and to survival in HCC patients with PVT.

Original languageEnglish
Pages (from-to)1141-1147
Number of pages7
JournalJournal of Gastrointestinal Cancer
Volume51
Issue number4
DOIs
Publication statusPublished - Dec 1 2020

Keywords

  • ESR
  • HCC
  • NLR
  • PLR
  • PVT
  • Survival

ASJC Scopus subject areas

  • Oncology
  • Gastroenterology

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