Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy

the AMD-Annals initiative

Marina Scavini, Maria Chiara Rossi, Marco Scardapane, Antonio Nicolucci, Valeria Manicardi, Giuseppina Russo, Paolo Di Bartolo, Carlo B Giorda, Nicoletta Musacchio, Antonio Ceriello, Stefano Genovese, Chiara Molinari, Nicoletta Dozio, AMD-Annals Study Group

Research output: Contribution to journalArticle

Abstract

AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.

METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin.

RESULTS: The proportion of T2D cases increased from 30.8% (95% CI 29.9-32.4) at age 18-30 years to 67.5% (66.6-68.5) at age 36-45 years. The proportion of women with HbA1c < 7.0% was 20.4% (20.0-20.8) in T1D and 43.4% (42.8-43.9) in T2D women. Furthermore, 47.6% (47.0-48.3) of T1D women and 34.5% (33.9-35.0) of T2D women had HbA1c ≥ 8.0%. The prevalence of obesity (BMI ≥ 30) was sevenfold higher among T2D than T1D women [49.9% (49.4-50.5) and 7.4% (7.2-7.5), respectively]. T2D women were more likely to have hypertension or microalbuminuria than T1D women. Almost half of the T2D women were taking drugs not approved during pregnancy. At least one unfavorable condition for starting a pregnancy was present in 51% of T1D women of childbearing age and in 66.7% of T2D women.

CONCLUSIONS: Women with either T1D or T2D of childbearing age in Italy were far from the ideal medical condition for conception. Our data strongly support the need for counseling all women with diabetes about pregnancy planning.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalActa Diabetologica
Volume55
Issue number2
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Type 2 Diabetes Mellitus
Italy
Pregnancy
Unplanned Pregnancy
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Metformin
Proteinuria
Angiotensin-Converting Enzyme Inhibitors
Pharmaceutical Preparations
Counseling
Obesity
Insulin
Hypertension

Keywords

  • Journal Article

Cite this

Scavini, M., Rossi, M. C., Scardapane, M., Nicolucci, A., Manicardi, V., Russo, G., ... AMD-Annals Study Group (2018). Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy: the AMD-Annals initiative. Acta Diabetologica, 55(2), 193-199. https://doi.org/10.1007/s00592-017-1076-9

Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy : the AMD-Annals initiative. / Scavini, Marina; Rossi, Maria Chiara; Scardapane, Marco; Nicolucci, Antonio; Manicardi, Valeria; Russo, Giuseppina; Di Bartolo, Paolo; Giorda, Carlo B; Musacchio, Nicoletta; Ceriello, Antonio; Genovese, Stefano; Molinari, Chiara; Dozio, Nicoletta; AMD-Annals Study Group.

In: Acta Diabetologica, Vol. 55, No. 2, 02.2018, p. 193-199.

Research output: Contribution to journalArticle

Scavini, M, Rossi, MC, Scardapane, M, Nicolucci, A, Manicardi, V, Russo, G, Di Bartolo, P, Giorda, CB, Musacchio, N, Ceriello, A, Genovese, S, Molinari, C, Dozio, N & AMD-Annals Study Group 2018, 'Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy: the AMD-Annals initiative', Acta Diabetologica, vol. 55, no. 2, pp. 193-199. https://doi.org/10.1007/s00592-017-1076-9
Scavini, Marina ; Rossi, Maria Chiara ; Scardapane, Marco ; Nicolucci, Antonio ; Manicardi, Valeria ; Russo, Giuseppina ; Di Bartolo, Paolo ; Giorda, Carlo B ; Musacchio, Nicoletta ; Ceriello, Antonio ; Genovese, Stefano ; Molinari, Chiara ; Dozio, Nicoletta ; AMD-Annals Study Group. / Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy : the AMD-Annals initiative. In: Acta Diabetologica. 2018 ; Vol. 55, No. 2. pp. 193-199.
@article{df72b98a10414df2b3da2d679840b170,
title = "Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy: the AMD-Annals initiative",
abstract = "AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0{\%}; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin.RESULTS: The proportion of T2D cases increased from 30.8{\%} (95{\%} CI 29.9-32.4) at age 18-30 years to 67.5{\%} (66.6-68.5) at age 36-45 years. The proportion of women with HbA1c < 7.0{\%} was 20.4{\%} (20.0-20.8) in T1D and 43.4{\%} (42.8-43.9) in T2D women. Furthermore, 47.6{\%} (47.0-48.3) of T1D women and 34.5{\%} (33.9-35.0) of T2D women had HbA1c ≥ 8.0{\%}. The prevalence of obesity (BMI ≥ 30) was sevenfold higher among T2D than T1D women [49.9{\%} (49.4-50.5) and 7.4{\%} (7.2-7.5), respectively]. T2D women were more likely to have hypertension or microalbuminuria than T1D women. Almost half of the T2D women were taking drugs not approved during pregnancy. At least one unfavorable condition for starting a pregnancy was present in 51{\%} of T1D women of childbearing age and in 66.7{\%} of T2D women.CONCLUSIONS: Women with either T1D or T2D of childbearing age in Italy were far from the ideal medical condition for conception. Our data strongly support the need for counseling all women with diabetes about pregnancy planning.",
keywords = "Journal Article",
author = "Marina Scavini and Rossi, {Maria Chiara} and Marco Scardapane and Antonio Nicolucci and Valeria Manicardi and Giuseppina Russo and {Di Bartolo}, Paolo and Giorda, {Carlo B} and Nicoletta Musacchio and Antonio Ceriello and Stefano Genovese and Chiara Molinari and Nicoletta Dozio and {AMD-Annals Study Group}",
year = "2018",
month = "2",
doi = "10.1007/s00592-017-1076-9",
language = "English",
volume = "55",
pages = "193--199",
journal = "Acta Diabetologica",
issn = "0940-5429",
publisher = "Springer-Verlag Italia s.r.l.",
number = "2",

}

TY - JOUR

T1 - Portrait of women with type 1 or type 2 diabetes of childbearing age attending diabetes clinics in Italy

T2 - the AMD-Annals initiative

AU - Scavini, Marina

AU - Rossi, Maria Chiara

AU - Scardapane, Marco

AU - Nicolucci, Antonio

AU - Manicardi, Valeria

AU - Russo, Giuseppina

AU - Di Bartolo, Paolo

AU - Giorda, Carlo B

AU - Musacchio, Nicoletta

AU - Ceriello, Antonio

AU - Genovese, Stefano

AU - Molinari, Chiara

AU - Dozio, Nicoletta

AU - AMD-Annals Study Group

PY - 2018/2

Y1 - 2018/2

N2 - AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin.RESULTS: The proportion of T2D cases increased from 30.8% (95% CI 29.9-32.4) at age 18-30 years to 67.5% (66.6-68.5) at age 36-45 years. The proportion of women with HbA1c < 7.0% was 20.4% (20.0-20.8) in T1D and 43.4% (42.8-43.9) in T2D women. Furthermore, 47.6% (47.0-48.3) of T1D women and 34.5% (33.9-35.0) of T2D women had HbA1c ≥ 8.0%. The prevalence of obesity (BMI ≥ 30) was sevenfold higher among T2D than T1D women [49.9% (49.4-50.5) and 7.4% (7.2-7.5), respectively]. T2D women were more likely to have hypertension or microalbuminuria than T1D women. Almost half of the T2D women were taking drugs not approved during pregnancy. At least one unfavorable condition for starting a pregnancy was present in 51% of T1D women of childbearing age and in 66.7% of T2D women.CONCLUSIONS: Women with either T1D or T2D of childbearing age in Italy were far from the ideal medical condition for conception. Our data strongly support the need for counseling all women with diabetes about pregnancy planning.

AB - AIM: To describe characteristics relevant in case of an unplanned pregnancy for T1D or T2D women of childbearing age.METHODS: We analyzed the 2011 AMD-Annals dataset, compiling information from 300 clinics (28,840 T1D patients and 532,651 T2D patients). A risk score of unfavorable conditions for pregnancy included HbA1c > 8.0%; BMI ≥ 35; systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg; microalbuminuria/proteinuria; use of statins, ACE inhibitors, ARB; use of diabetes drugs other than metformin/insulin.RESULTS: The proportion of T2D cases increased from 30.8% (95% CI 29.9-32.4) at age 18-30 years to 67.5% (66.6-68.5) at age 36-45 years. The proportion of women with HbA1c < 7.0% was 20.4% (20.0-20.8) in T1D and 43.4% (42.8-43.9) in T2D women. Furthermore, 47.6% (47.0-48.3) of T1D women and 34.5% (33.9-35.0) of T2D women had HbA1c ≥ 8.0%. The prevalence of obesity (BMI ≥ 30) was sevenfold higher among T2D than T1D women [49.9% (49.4-50.5) and 7.4% (7.2-7.5), respectively]. T2D women were more likely to have hypertension or microalbuminuria than T1D women. Almost half of the T2D women were taking drugs not approved during pregnancy. At least one unfavorable condition for starting a pregnancy was present in 51% of T1D women of childbearing age and in 66.7% of T2D women.CONCLUSIONS: Women with either T1D or T2D of childbearing age in Italy were far from the ideal medical condition for conception. Our data strongly support the need for counseling all women with diabetes about pregnancy planning.

KW - Journal Article

U2 - 10.1007/s00592-017-1076-9

DO - 10.1007/s00592-017-1076-9

M3 - Article

VL - 55

SP - 193

EP - 199

JO - Acta Diabetologica

JF - Acta Diabetologica

SN - 0940-5429

IS - 2

ER -