Portraying infective endocarditis

results of multinational ID-IRI study

Hakan Erdem, Edmond Puca, Yvon Ruch, Lurdes Santos, Nesrin Ghanem-Zoubi, Xavier Argemi, Yves Hansmann, Rahmet Guner, Gilda Tonziello, Jean Philippe Mazzucotelli, Najada Como, Sukran Kose, Ayse Batirel, Asuman Inan, Necla Tulek, Abdullah Umut Pekok, Ejaz Ahmed Khan, Atilla Iyisoy, Meliha Meric-Koc, Ayse Kaya-Kalem & 41 others Pedro Palma Martins, Imran Hasanoglu, André Silva-Pinto, Nefise Oztoprak, Raquel Duro, Fahad Almajid, Mustafa Dogan, Nicolas Dauby, Jesper Damsgaard Gunst, Recep Tekin, Deborah Konopnicki, Nicola Petrosillo, Ilkay Bozkurt, Jamal Wadi, Corneliu Popescu, Ilker Inanc Balkan, Safak Ozer-Balin, Tatjana Lejko Zupanc, Antonio Cascio, Irina Magdalena Dumitru, Aysegul Erdem, Gulden Ersoz, Meltem Tasbakan, Oday Abu Ajamieh, Fatma Sirmatel, Simin Florescu, Serda Gulsun, Hacer Deniz Ozkaya, Sema Sari, Selma Tosun, Meltem Avci, Yasemin Cag, Guven Celebi, Ayse Sagmak-Tartar, Sumeyra Karakus, Alper Sener, Arjeta Dedej, Serkan Oncu, Rosa Fontana Del Vecchio, Derya Ozturk-Engin, Canan Agalar

Research output: Contribution to journalArticle

Abstract

Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

Original languageEnglish
Pages (from-to)1753-1763
Number of pages11
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
DOIs
Publication statusPublished - Jan 1 2019

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Endocarditis
Viridans Streptococci
Vascular Access Devices
Coagulase
Enterococcus
Mitral Valve
Staphylococcus
Abscess
Staphylococcus aureus

Keywords

  • Blood culture
  • Infective endocarditis
  • Native
  • Prosthetic
  • S. aureus

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Portraying infective endocarditis : results of multinational ID-IRI study. / Erdem, Hakan; Puca, Edmond; Ruch, Yvon; Santos, Lurdes; Ghanem-Zoubi, Nesrin; Argemi, Xavier; Hansmann, Yves; Guner, Rahmet; Tonziello, Gilda; Mazzucotelli, Jean Philippe; Como, Najada; Kose, Sukran; Batirel, Ayse; Inan, Asuman; Tulek, Necla; Pekok, Abdullah Umut; Khan, Ejaz Ahmed; Iyisoy, Atilla; Meric-Koc, Meliha; Kaya-Kalem, Ayse; Martins, Pedro Palma; Hasanoglu, Imran; Silva-Pinto, André; Oztoprak, Nefise; Duro, Raquel; Almajid, Fahad; Dogan, Mustafa; Dauby, Nicolas; Gunst, Jesper Damsgaard; Tekin, Recep; Konopnicki, Deborah; Petrosillo, Nicola; Bozkurt, Ilkay; Wadi, Jamal; Popescu, Corneliu; Balkan, Ilker Inanc; Ozer-Balin, Safak; Zupanc, Tatjana Lejko; Cascio, Antonio; Dumitru, Irina Magdalena; Erdem, Aysegul; Ersoz, Gulden; Tasbakan, Meltem; Ajamieh, Oday Abu; Sirmatel, Fatma; Florescu, Simin; Gulsun, Serda; Ozkaya, Hacer Deniz; Sari, Sema; Tosun, Selma; Avci, Meltem; Cag, Yasemin; Celebi, Guven; Sagmak-Tartar, Ayse; Karakus, Sumeyra; Sener, Alper; Dedej, Arjeta; Oncu, Serkan; Del Vecchio, Rosa Fontana; Ozturk-Engin, Derya; Agalar, Canan.

In: European Journal of Clinical Microbiology and Infectious Diseases, 01.01.2019, p. 1753-1763.

Research output: Contribution to journalArticle

Erdem, H, Puca, E, Ruch, Y, Santos, L, Ghanem-Zoubi, N, Argemi, X, Hansmann, Y, Guner, R, Tonziello, G, Mazzucotelli, JP, Como, N, Kose, S, Batirel, A, Inan, A, Tulek, N, Pekok, AU, Khan, EA, Iyisoy, A, Meric-Koc, M, Kaya-Kalem, A, Martins, PP, Hasanoglu, I, Silva-Pinto, A, Oztoprak, N, Duro, R, Almajid, F, Dogan, M, Dauby, N, Gunst, JD, Tekin, R, Konopnicki, D, Petrosillo, N, Bozkurt, I, Wadi, J, Popescu, C, Balkan, II, Ozer-Balin, S, Zupanc, TL, Cascio, A, Dumitru, IM, Erdem, A, Ersoz, G, Tasbakan, M, Ajamieh, OA, Sirmatel, F, Florescu, S, Gulsun, S, Ozkaya, HD, Sari, S, Tosun, S, Avci, M, Cag, Y, Celebi, G, Sagmak-Tartar, A, Karakus, S, Sener, A, Dedej, A, Oncu, S, Del Vecchio, RF, Ozturk-Engin, D & Agalar, C 2019, 'Portraying infective endocarditis: results of multinational ID-IRI study', European Journal of Clinical Microbiology and Infectious Diseases, pp. 1753-1763. https://doi.org/10.1007/s10096-019-03607-x
Erdem, Hakan ; Puca, Edmond ; Ruch, Yvon ; Santos, Lurdes ; Ghanem-Zoubi, Nesrin ; Argemi, Xavier ; Hansmann, Yves ; Guner, Rahmet ; Tonziello, Gilda ; Mazzucotelli, Jean Philippe ; Como, Najada ; Kose, Sukran ; Batirel, Ayse ; Inan, Asuman ; Tulek, Necla ; Pekok, Abdullah Umut ; Khan, Ejaz Ahmed ; Iyisoy, Atilla ; Meric-Koc, Meliha ; Kaya-Kalem, Ayse ; Martins, Pedro Palma ; Hasanoglu, Imran ; Silva-Pinto, André ; Oztoprak, Nefise ; Duro, Raquel ; Almajid, Fahad ; Dogan, Mustafa ; Dauby, Nicolas ; Gunst, Jesper Damsgaard ; Tekin, Recep ; Konopnicki, Deborah ; Petrosillo, Nicola ; Bozkurt, Ilkay ; Wadi, Jamal ; Popescu, Corneliu ; Balkan, Ilker Inanc ; Ozer-Balin, Safak ; Zupanc, Tatjana Lejko ; Cascio, Antonio ; Dumitru, Irina Magdalena ; Erdem, Aysegul ; Ersoz, Gulden ; Tasbakan, Meltem ; Ajamieh, Oday Abu ; Sirmatel, Fatma ; Florescu, Simin ; Gulsun, Serda ; Ozkaya, Hacer Deniz ; Sari, Sema ; Tosun, Selma ; Avci, Meltem ; Cag, Yasemin ; Celebi, Guven ; Sagmak-Tartar, Ayse ; Karakus, Sumeyra ; Sener, Alper ; Dedej, Arjeta ; Oncu, Serkan ; Del Vecchio, Rosa Fontana ; Ozturk-Engin, Derya ; Agalar, Canan. / Portraying infective endocarditis : results of multinational ID-IRI study. In: European Journal of Clinical Microbiology and Infectious Diseases. 2019 ; pp. 1753-1763.
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abstract = "Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8{\%}) patients had native valve endocarditis (NVE), 214 (24.7{\%}) patients had prosthetic valve endocarditis (PVE), 21 (2.4{\%}) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9{\%}. A total of 385 (44.4{\%}) patients had major embolic events, most frequently to the brain (n = 227, 26.3{\%}). Blood cultures yielded pathogens in 766 (88.4{\%}). In 101 (11.6{\%}) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7{\%}) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6{\%}), Streptococcus viridans (n = 149, 18.7{\%}), enterococci (n = 128, 16.1{\%}), coagulase-negative staphylococci (n = 92, 11.6{\%})) displayed substantial resistance profiles. A total of 132 (15.2{\%}) patients had cardiac abscesses; 693 (79.9{\%}) patients had left-sided endocarditis. Aortic (n = 394, 45.4{\%}) and mitral valves (n = 369, 42.5{\%}) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16{\%}), PVE (n = 49, 22.9{\%}), p = 0.042).",
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T1 - Portraying infective endocarditis

T2 - results of multinational ID-IRI study

AU - Erdem, Hakan

AU - Puca, Edmond

AU - Ruch, Yvon

AU - Santos, Lurdes

AU - Ghanem-Zoubi, Nesrin

AU - Argemi, Xavier

AU - Hansmann, Yves

AU - Guner, Rahmet

AU - Tonziello, Gilda

AU - Mazzucotelli, Jean Philippe

AU - Como, Najada

AU - Kose, Sukran

AU - Batirel, Ayse

AU - Inan, Asuman

AU - Tulek, Necla

AU - Pekok, Abdullah Umut

AU - Khan, Ejaz Ahmed

AU - Iyisoy, Atilla

AU - Meric-Koc, Meliha

AU - Kaya-Kalem, Ayse

AU - Martins, Pedro Palma

AU - Hasanoglu, Imran

AU - Silva-Pinto, André

AU - Oztoprak, Nefise

AU - Duro, Raquel

AU - Almajid, Fahad

AU - Dogan, Mustafa

AU - Dauby, Nicolas

AU - Gunst, Jesper Damsgaard

AU - Tekin, Recep

AU - Konopnicki, Deborah

AU - Petrosillo, Nicola

AU - Bozkurt, Ilkay

AU - Wadi, Jamal

AU - Popescu, Corneliu

AU - Balkan, Ilker Inanc

AU - Ozer-Balin, Safak

AU - Zupanc, Tatjana Lejko

AU - Cascio, Antonio

AU - Dumitru, Irina Magdalena

AU - Erdem, Aysegul

AU - Ersoz, Gulden

AU - Tasbakan, Meltem

AU - Ajamieh, Oday Abu

AU - Sirmatel, Fatma

AU - Florescu, Simin

AU - Gulsun, Serda

AU - Ozkaya, Hacer Deniz

AU - Sari, Sema

AU - Tosun, Selma

AU - Avci, Meltem

AU - Cag, Yasemin

AU - Celebi, Guven

AU - Sagmak-Tartar, Ayse

AU - Karakus, Sumeyra

AU - Sener, Alper

AU - Dedej, Arjeta

AU - Oncu, Serkan

AU - Del Vecchio, Rosa Fontana

AU - Ozturk-Engin, Derya

AU - Agalar, Canan

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

AB - Infective endocarditis is a growing problem with many shifts due to ever-increasing comorbid illnesses, invasive procedures, and increase in the elderly. We performed this multinational study to depict definite infective endocarditis. Adult patients with definite endocarditis hospitalized between January 1, 2015, and October 1, 2018, were included from 41 hospitals in 13 countries. We included microbiological features, types and severity of the disease, complications, but excluded therapeutic parameters. A total of 867 patients were included. A total of 631 (72.8%) patients had native valve endocarditis (NVE), 214 (24.7%) patients had prosthetic valve endocarditis (PVE), 21 (2.4%) patients had pacemaker lead endocarditis, and 1 patient had catheter port endocarditis. Eighteen percent of NVE patients were hospital-acquired. PVE patients were classified as early-onset in 24.9%. A total of 385 (44.4%) patients had major embolic events, most frequently to the brain (n = 227, 26.3%). Blood cultures yielded pathogens in 766 (88.4%). In 101 (11.6%) patients, blood cultures were negative. Molecular testing of vegetations disclosed pathogens in 65 cases. Overall, 795 (91.7%) endocarditis patients had any identified pathogen. Leading pathogens (Staphylococcus aureus (n = 267, 33.6%), Streptococcus viridans (n = 149, 18.7%), enterococci (n = 128, 16.1%), coagulase-negative staphylococci (n = 92, 11.6%)) displayed substantial resistance profiles. A total of 132 (15.2%) patients had cardiac abscesses; 693 (79.9%) patients had left-sided endocarditis. Aortic (n = 394, 45.4%) and mitral valves (n = 369, 42.5%) were most frequently involved. Mortality was more common in PVE than NVE (NVE (n = 101, 16%), PVE (n = 49, 22.9%), p = 0.042).

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KW - Prosthetic

KW - S. aureus

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