Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?

Corrado Girmenia, Luciana Annino, B. Mariotti, R. Fanci, Clara Minotti, Antonio Spadea, A. Carotti, Monica Piedimonte, A. Chierichini, Elisabetta Cerchiara, Desiree Caselli, L. Cupelli, Francesco Arcioni, Alice Bertaina, Michela Ribersani, A. Proia, Andrea Mengarelli, Vincenzo Perriello, Giovanni Fernando Torelli, M. Di GioiaMaria Ilaria Del Principe, Maria Iris Cassetta, Stefania Fallani, Andrea Novelli

Research output: Contribution to journalArticle

Abstract

Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (≥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC

Original languageEnglish
Pages (from-to)445-458
Number of pages14
JournalMedical Mycology
Volume54
Issue number5
DOIs
Publication statusPublished - Jul 1 2016

Keywords

  • acute leukemia
  • allogeneic stem cell transplant
  • diarrhea
  • plasma level
  • posaconazole

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?'. Together they form a unique fingerprint.

  • Cite this

    Girmenia, C., Annino, L., Mariotti, B., Fanci, R., Minotti, C., Spadea, A., Carotti, A., Piedimonte, M., Chierichini, A., Cerchiara, E., Caselli, D., Cupelli, L., Arcioni, F., Bertaina, A., Ribersani, M., Proia, A., Mengarelli, A., Perriello, V., Torelli, G. F., ... Novelli, A. (2016). Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration? Medical Mycology, 54(5), 445-458. https://doi.org/10.1093/mmy/myw001