Abstract
Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (≥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC
Original language | English |
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Pages (from-to) | 445-458 |
Number of pages | 14 |
Journal | Medical Mycology |
Volume | 54 |
Issue number | 5 |
DOIs | |
Publication status | Published - Jul 1 2016 |
Keywords
- acute leukemia
- allogeneic stem cell transplant
- diarrhea
- plasma level
- posaconazole
ASJC Scopus subject areas
- veterinary(all)
- Infectious Diseases