Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?

Corrado Girmenia; Luciana Annino; B. Mariotti; R. Fanci; Clara Minotti; Antonio Spadea; A. Carotti; Monica Piedimonte; A. Chierichini; Elisabetta Cerchiara; Desiree Caselli; L. Cupelli; Francesco Arcioni; Alice Bertaina; Michela Ribersani; A. Proia; Andrea Mengarelli; Vincenzo Perriello; Giovanni Fernando Torelli; M. Di Gioia; Maria Ilaria Del Principe; Maria Iris Cassetta; Stefania Fallani; Andrea Novelli

doi:10.1093/mmy/myw001

Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?

Corrado Girmenia, Luciana Annino, B. Mariotti, R. Fanci, Clara Minotti, Antonio Spadea, A. Carotti, Monica Piedimonte, A. Chierichini, Elisabetta Cerchiara, Desiree Caselli, L. Cupelli, Francesco Arcioni, Alice Bertaina, Michela Ribersani, A. Proia, Andrea Mengarelli, Vincenzo Perriello, Giovanni Fernando Torelli, M. Di GioiaMaria Ilaria Del Principe, Maria Iris Cassetta, Stefania Fallani, Andrea Novelli

Research output: Contribution to journal › Article › peer-review

Abstract

Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (â‰¥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC

Original language	English
Pages (from-to)	445-458
Number of pages	14
Journal	Medical Mycology
Volume	54
Issue number	5
DOIs	https://doi.org/10.1093/mmy/myw001
Publication status	Published - Jul 1 2016

Keywords

acute leukemia
allogeneic stem cell transplant
diarrhea
plasma level
posaconazole

ASJC Scopus subject areas

veterinary(all)
Infectious Diseases

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10.1093/mmy/myw001

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Girmenia, C., Annino, L., Mariotti, B., Fanci, R., Minotti, C., Spadea, A., Carotti, A., Piedimonte, M., Chierichini, A., Cerchiara, E., Caselli, D., Cupelli, L., Arcioni, F., Bertaina, A., Ribersani, M., Proia, A., Mengarelli, A., Perriello, V., Torelli, G. F., ... Novelli, A. (2016). Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration? Medical Mycology, 54(5), 445-458. https://doi.org/10.1093/mmy/myw001

Girmenia, C, Annino, L, Mariotti, B, Fanci, R, Minotti, C, Spadea, A, Carotti, A, Piedimonte, M, Chierichini, A, Cerchiara, E, Caselli, D, Cupelli, L, Arcioni, F, Bertaina, A, Ribersani, M, Proia, A, Mengarelli, A, Perriello, V, Torelli, GF, Di Gioia, M, Del Principe, MI, Cassetta, MI, Fallani, S & Novelli, A 2016, 'Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?', Medical Mycology, vol. 54, no. 5, pp. 445-458. https://doi.org/10.1093/mmy/myw001

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abstract = "Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state ({\^a}‰¥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC ",

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author = "Corrado Girmenia and Luciana Annino and B. Mariotti and R. Fanci and Clara Minotti and Antonio Spadea and A. Carotti and Monica Piedimonte and A. Chierichini and Elisabetta Cerchiara and Desiree Caselli and L. Cupelli and Francesco Arcioni and Alice Bertaina and Michela Ribersani and A. Proia and Andrea Mengarelli and Vincenzo Perriello and Torelli, {Giovanni Fernando} and {Di Gioia}, M. and {Del Principe}, {Maria Ilaria} and Cassetta, {Maria Iris} and Stefania Fallani and Andrea Novelli",

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T1 - Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients

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AU - Girmenia, Corrado

AU - Annino, Luciana

AU - Mariotti, B.

AU - Fanci, R.

AU - Minotti, Clara

AU - Spadea, Antonio

AU - Carotti, A.

AU - Piedimonte, Monica

AU - Chierichini, A.

AU - Cerchiara, Elisabetta

AU - Caselli, Desiree

AU - Cupelli, L.

AU - Arcioni, Francesco

AU - Bertaina, Alice

AU - Ribersani, Michela

AU - Proia, A.

AU - Mengarelli, Andrea

AU - Perriello, Vincenzo

AU - Torelli, Giovanni Fernando

AU - Di Gioia, M.

AU - Del Principe, Maria Ilaria

AU - Cassetta, Maria Iris

AU - Fallani, Stefania

AU - Novelli, Andrea

PY - 2016/7/1

Y1 - 2016/7/1

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Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?

Abstract

Keywords

ASJC Scopus subject areas

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