Abstract
Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (≥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC
| Original language | English |
|---|---|
| Pages (from-to) | 445-458 |
| Number of pages | 14 |
| Journal | Medical Mycology |
| Volume | 54 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - Jul 1 2016 |
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Keywords
- acute leukemia
- allogeneic stem cell transplant
- diarrhea
- plasma level
- posaconazole
ASJC Scopus subject areas
- veterinary(all)
- Infectious Diseases
Cite this
Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients : can it be used without measurement of plasma concentration? / Girmenia, Corrado; Annino, Luciana; Mariotti, B.; Fanci, R.; Minotti, Clara; Spadea, Antonio; Carotti, A.; Piedimonte, Monica; Chierichini, A.; Cerchiara, Elisabetta; Caselli, Desiree; Cupelli, L.; Arcioni, Francesco; Bertaina, Alice; Ribersani, Michela; Proia, A.; Mengarelli, Andrea; Perriello, Vincenzo; Torelli, Giovanni Fernando; Di Gioia, M.; Del Principe, Maria Ilaria; Cassetta, Maria Iris; Fallani, Stefania; Novelli, Andrea.
In: Medical Mycology, Vol. 54, No. 5, 01.07.2016, p. 445-458.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients
T2 - can it be used without measurement of plasma concentration?
AU - Girmenia, Corrado
AU - Annino, Luciana
AU - Mariotti, B.
AU - Fanci, R.
AU - Minotti, Clara
AU - Spadea, Antonio
AU - Carotti, A.
AU - Piedimonte, Monica
AU - Chierichini, A.
AU - Cerchiara, Elisabetta
AU - Caselli, Desiree
AU - Cupelli, L.
AU - Arcioni, Francesco
AU - Bertaina, Alice
AU - Ribersani, Michela
AU - Proia, A.
AU - Mengarelli, Andrea
AU - Perriello, Vincenzo
AU - Torelli, Giovanni Fernando
AU - Di Gioia, M.
AU - Del Principe, Maria Ilaria
AU - Cassetta, Maria Iris
AU - Fallani, Stefania
AU - Novelli, Andrea
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (≥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC
AB - Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patients receiving PCZ-susp. In this prospective, multicenter study we evaluated the variability of PPCs in hematologic patients receiving PCZ-susp prophylaxis with the aim to define conditions at different risk of subtherapeutic PPCs. Overall, 103 acute leukemia (AL) patients submitted to intensive chemotherapy (115 courses) and 46 allogeneic stem cell transplant (allo-SCT) recipients (47 courses) receiving PCZ-susp prophylaxis were considered. The adequacy of PPC pattern after the steady state (≥day 7 of treatment) in courses with two or more PPC measurements was defined as follows: inadequate pattern: PPC
KW - acute leukemia
KW - allogeneic stem cell transplant
KW - diarrhea
KW - plasma level
KW - posaconazole
UR - http://www.scopus.com/inward/record.url?scp=84981714812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84981714812&partnerID=8YFLogxK
U2 - 10.1093/mmy/myw001
DO - 10.1093/mmy/myw001
M3 - Article
VL - 54
SP - 445
EP - 458
JO - Medical Mycology
JF - Medical Mycology
SN - 1369-3786
IS - 5
ER -