Position Paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

Marry M. Van Den Heuvel-Eibrink, Janna A. Hol, Kathy Pritchard-Jones, Harm Van Tinteren, Rhoikos Furtwängler, Arnauld C. Verschuur, Gordan M. Vujanic, Ivo Leuschner, Jesper Brok, Christian Rübe, Anne M. Smets, Geert O. Janssens, Jan Godzinski, Gema L. Ramírez-Villar, Beatriz De Camargo, Heidi Segers, Paola Collini, Manfred Gessler, Christophe Bergeron, Filippo SpreaficoNorbert Graf

Research output: Contribution to journalArticlepeer-review


The Renal Tumour Study Group of the International Society of Paediatric Oncology (SIOP-RTSG) has developed a new protocol for the diagnosis and treatment of childhood renal tumours, the UMBRELLA SIOP-RTSG 2016 (the UMBRELLA protocol), to continue international collaboration in the treatment of childhood renal tumours. This protocol will support integrated biomarker and imaging research, focussing on assessing the independent prognostic value of genomic changes within the tumour and the volume of the blastemal component that survives preoperative chemotherapy. Treatment guidelines for Wilms tumours in the UMBRELLA protocol include recommendations for localized, metastatic, and bilateral disease, for all age groups, and for relapsed disease. These recommendations have been established by a multidisciplinary panel of leading experts on renal tumours within the SIOP-RTSG. The UMBRELLA protocol should promote international collaboration and research and serve as the SIOP-RTSG best available treatment standard.

Original languageEnglish
Pages (from-to)743-752
Number of pages10
JournalNature Reviews Urology
Issue number12
Publication statusPublished - Dec 1 2017

ASJC Scopus subject areas

  • Urology


Dive into the research topics of 'Position Paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol'. Together they form a unique fingerprint.

Cite this