Abstract
Background The role of prone position in preterm infants has not been completely clarified. We investigated prone versus supine posture-related changes in respiratory system resistance (Rrs) and reactance (Xrs) measured by the Forced Oscillation Technique (FOT) in mechanically ventilated preterm newborns. Methods Patients were studied in the supine versus prone positions in random order. Oxygen saturation, transcutaneous partial pressure of oxygen (ptcO2), carbon dioxide (ptcCO2), Rrs and Xrs were measured in each position. Results Nine patients with respiratory distress syndrome (RDS) and nine with evolving broncho-pulmonary dysplasia (BPD) were studied. Rrs was, on average, 9.8 (1.3, 18.3 as 95%CI) cmH2Os/l lower in the prone compared to the supine position (P = 0.02), while no differences in Xrs, ptcO2, ptcCO2, and breathing pattern were observed between postures. Only patients with evolving BPD showed a significant reduction of Rrs from 69.0 ± 27.4 to 53.0 ± 16.7 cmH2Os/l, P = 0.01. No significant correlations were found between changes in lung mechanics and ptcO2, ptcCO2, or breathing pattern. Conclusions On short-term basis, prone positioning does not offer significant advantages in lung mechanics in mechanically ventilated infants with RDS, while it is associated with lower Rrs values in patients with evolving BPD. Pediatr Pulmonol. 2015; 50:798-804.
| Original language | English |
|---|---|
| Pages (from-to) | 798-804 |
| Number of pages | 7 |
| Journal | Pediatric Pulmonology |
| Volume | 50 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2015 |
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Keywords
- infant pulmonary function
- mechanical ventilation
- neonatal pulmonary medicine
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Pulmonary and Respiratory Medicine
Cite this
Positional effects on lung mechanics of ventilated preterm infants with acute and chronic lung disease. / Vendettuoli, V.; Veneroni, C.; Zannin, E.; Mercadante, D.; Matassa, P.; Pedotti, A.; Colnaghi, M.; Dellacà, R. L.; Mosca, F.
In: Pediatric Pulmonology, Vol. 50, No. 8, 01.08.2015, p. 798-804.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Positional effects on lung mechanics of ventilated preterm infants with acute and chronic lung disease
AU - Vendettuoli, V.
AU - Veneroni, C.
AU - Zannin, E.
AU - Mercadante, D.
AU - Matassa, P.
AU - Pedotti, A.
AU - Colnaghi, M.
AU - Dellacà, R. L.
AU - Mosca, F.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background The role of prone position in preterm infants has not been completely clarified. We investigated prone versus supine posture-related changes in respiratory system resistance (Rrs) and reactance (Xrs) measured by the Forced Oscillation Technique (FOT) in mechanically ventilated preterm newborns. Methods Patients were studied in the supine versus prone positions in random order. Oxygen saturation, transcutaneous partial pressure of oxygen (ptcO2), carbon dioxide (ptcCO2), Rrs and Xrs were measured in each position. Results Nine patients with respiratory distress syndrome (RDS) and nine with evolving broncho-pulmonary dysplasia (BPD) were studied. Rrs was, on average, 9.8 (1.3, 18.3 as 95%CI) cmH2Os/l lower in the prone compared to the supine position (P = 0.02), while no differences in Xrs, ptcO2, ptcCO2, and breathing pattern were observed between postures. Only patients with evolving BPD showed a significant reduction of Rrs from 69.0 ± 27.4 to 53.0 ± 16.7 cmH2Os/l, P = 0.01. No significant correlations were found between changes in lung mechanics and ptcO2, ptcCO2, or breathing pattern. Conclusions On short-term basis, prone positioning does not offer significant advantages in lung mechanics in mechanically ventilated infants with RDS, while it is associated with lower Rrs values in patients with evolving BPD. Pediatr Pulmonol. 2015; 50:798-804.
AB - Background The role of prone position in preterm infants has not been completely clarified. We investigated prone versus supine posture-related changes in respiratory system resistance (Rrs) and reactance (Xrs) measured by the Forced Oscillation Technique (FOT) in mechanically ventilated preterm newborns. Methods Patients were studied in the supine versus prone positions in random order. Oxygen saturation, transcutaneous partial pressure of oxygen (ptcO2), carbon dioxide (ptcCO2), Rrs and Xrs were measured in each position. Results Nine patients with respiratory distress syndrome (RDS) and nine with evolving broncho-pulmonary dysplasia (BPD) were studied. Rrs was, on average, 9.8 (1.3, 18.3 as 95%CI) cmH2Os/l lower in the prone compared to the supine position (P = 0.02), while no differences in Xrs, ptcO2, ptcCO2, and breathing pattern were observed between postures. Only patients with evolving BPD showed a significant reduction of Rrs from 69.0 ± 27.4 to 53.0 ± 16.7 cmH2Os/l, P = 0.01. No significant correlations were found between changes in lung mechanics and ptcO2, ptcCO2, or breathing pattern. Conclusions On short-term basis, prone positioning does not offer significant advantages in lung mechanics in mechanically ventilated infants with RDS, while it is associated with lower Rrs values in patients with evolving BPD. Pediatr Pulmonol. 2015; 50:798-804.
KW - infant pulmonary function
KW - mechanical ventilation
KW - neonatal pulmonary medicine
UR - http://www.scopus.com/inward/record.url?scp=84937023122&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84937023122&partnerID=8YFLogxK
U2 - 10.1002/ppul.23049
DO - 10.1002/ppul.23049
M3 - Article
C2 - 24706414
AN - SCOPUS:84937023122
VL - 50
SP - 798
EP - 804
JO - Pediatric Pulmonology
JF - Pediatric Pulmonology
SN - 8755-6863
IS - 8
ER -