Positioning the isthmic organizer - Where Otx2 and Gbx2 meet

Antonio Simeone

Research output: Contribution to journalArticle

Abstract

Regional diversity along the anterior-posterior axis of the central nervous system is established during gastrulation and is subsequently refined by local organizing centres that are located at genetically defined positions. The isthmic organizer possesses midbrain- and cerebellum-inducing properties, and its positioning at the midbrain-hindbrain boundary is a crucial event that controls midbrain and cerebellum development. Recent work has shown that two transcription factors, Otx2 and Gbx2, are instrumental in positioning the isthmic organizer at the midbrain-hindbrain boundary.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalTrends in Genetics
Volume16
Issue number6
DOIs
Publication statusPublished - Jun 1 2000

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Mesencephalon
Rhombencephalon
Otx Transcription Factors
Cerebellum
Gastrulation
Central Nervous System

ASJC Scopus subject areas

  • Genetics

Cite this

Positioning the isthmic organizer - Where Otx2 and Gbx2 meet. / Simeone, Antonio.

In: Trends in Genetics, Vol. 16, No. 6, 01.06.2000, p. 237-240.

Research output: Contribution to journalArticle

Simeone, Antonio. / Positioning the isthmic organizer - Where Otx2 and Gbx2 meet. In: Trends in Genetics. 2000 ; Vol. 16, No. 6. pp. 237-240.
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