Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension

Maurizio Galderisi, Pio Caso, Silvana Cicala, Luigi De Simone, Michelangela Barbieri, Giovanni Vitale, Oreste De Divitiis, Giuseppe Paolisso

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Background: The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and endothelial function. Methods: A total of 44 newly diagnosed, untreated hypertensive patients, who were free of diabetes mellitus and coronary artery disease, underwent M-mode analysis, second-harmonic Doppler echocardiographic assessment of CFR (dipyridamole infusion 0.56 mg/kg intravenously in four patients), determination of circulating free IGF-1, and insulin resistance. Based on CFR levels, hypertensive subjects were divided into two groups: 18 with normal CFR (≥2) and 26 with impaired CFR (

Original languageEnglish
Pages (from-to)766-772
Number of pages7
JournalAmerican Journal of Hypertension
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2002

Fingerprint

Somatomedins
Hypertension
Dipyridamole
Insulin Resistance
Coronary Artery Disease
Diabetes Mellitus

Keywords

  • Blood flow
  • Doppler echocardiography
  • Growth substances
  • Hypertension
  • Insulin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension. / Galderisi, Maurizio; Caso, Pio; Cicala, Silvana; De Simone, Luigi; Barbieri, Michelangela; Vitale, Giovanni; De Divitiis, Oreste; Paolisso, Giuseppe.

In: American Journal of Hypertension, Vol. 15, No. 9, 09.2002, p. 766-772.

Research output: Contribution to journalArticle

Galderisi, Maurizio ; Caso, Pio ; Cicala, Silvana ; De Simone, Luigi ; Barbieri, Michelangela ; Vitale, Giovanni ; De Divitiis, Oreste ; Paolisso, Giuseppe. / Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension. In: American Journal of Hypertension. 2002 ; Vol. 15, No. 9. pp. 766-772.
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AU - Barbieri, Michelangela

AU - Vitale, Giovanni

AU - De Divitiis, Oreste

AU - Paolisso, Giuseppe

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