Positive association between circulating free insulin-like growth factor-1 levels and coronary flow reserve in arterial systemic hypertension

Maurizio Galderisi, Pio Caso, Silvana Cicala, Luigi De Simone, Michelangela Barbieri, Giovanni Vitale, Oreste De Divitiis, Giuseppe Paolisso

Research output: Contribution to journalArticle

Abstract

Background: The reduction of coronary flow reserve (CFR) found in arterial hypertension may be due to changes in afterload, left ventricular (LV) structure, and metabolic factors. Also, insulin-like growth factor-1 (IGF-1) may be associated with the magnitude of CFR in relation to its modulating action on cardiac and endothelial function. Methods: A total of 44 newly diagnosed, untreated hypertensive patients, who were free of diabetes mellitus and coronary artery disease, underwent M-mode analysis, second-harmonic Doppler echocardiographic assessment of CFR (dipyridamole infusion 0.56 mg/kg intravenously in four patients), determination of circulating free IGF-1, and insulin resistance. Based on CFR levels, hypertensive subjects were divided into two groups: 18 with normal CFR (≥2) and 26 with impaired CFR (

Original languageEnglish
Pages (from-to)766-772
Number of pages7
JournalAmerican Journal of Hypertension
Volume15
Issue number9
DOIs
Publication statusPublished - Sep 2002

Keywords

  • Blood flow
  • Doppler echocardiography
  • Growth substances
  • Hypertension
  • Insulin

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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