Abstract
Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
Original language | English |
---|---|
Pages (from-to) | 1-4 |
Number of pages | 4 |
Journal | SpringerPlus |
Volume | 3 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2014 |
Keywords
- Inflammation
- Ischemia/reperfusion
- Kidney disease
- Kidney transplantation
- Radical oxygen species
ASJC Scopus subject areas
- General