Abstract
Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Number of pages | 4 |
| Journal | SpringerPlus |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Inflammation
- Ischemia/reperfusion
- Kidney disease
- Kidney transplantation
- Radical oxygen species
ASJC Scopus subject areas
- General
Cite this
Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion : A preliminary report. / Bassi, Roberto; Vergani, Andrea; D'Addio, Francesca; Nasr, Moufida Ben; Mocci, Alessio; Rastaldi, Maria Pia; Ichimura, Takaharu; Bonventre, Joseph Vincent; Fiorina, Paolo.
In: SpringerPlus, Vol. 3, No. 1, 2014, p. 1-4.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion
T2 - A preliminary report
AU - Bassi, Roberto
AU - Vergani, Andrea
AU - D'Addio, Francesca
AU - Nasr, Moufida Ben
AU - Mocci, Alessio
AU - Rastaldi, Maria Pia
AU - Ichimura, Takaharu
AU - Bonventre, Joseph Vincent
AU - Fiorina, Paolo
PY - 2014
Y1 - 2014
N2 - Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
AB - Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.
KW - Inflammation
KW - Ischemia/reperfusion
KW - Kidney disease
KW - Kidney transplantation
KW - Radical oxygen species
UR - http://www.scopus.com/inward/record.url?scp=84899530854&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899530854&partnerID=8YFLogxK
U2 - 10.1186/2193-1801-3-158
DO - 10.1186/2193-1801-3-158
M3 - Article
VL - 3
SP - 1
EP - 4
JO - SpringerPlus
JF - SpringerPlus
SN - 2193-1801
IS - 1
ER -