Positive effects of a novel non-peptidyl low molecular weight radical scavenger in renal ischemia/reperfusion: A preliminary report

Roberto Bassi, Andrea Vergani, Francesca D'Addio, Moufida Ben Nasr, Alessio Mocci, Maria Pia Rastaldi, Takaharu Ichimura, Joseph Vincent Bonventre, Paolo Fiorina

Research output: Contribution to journalArticle

Abstract

Ischemia/reperfusion (I/R) is one of the most common causes of acute kidney injury. Reactive oxygen species have been recognized to be an important contributor to the pathogenesis of I/R injury. We hypothesize that a non-peptidyl low molecular weight radical scavenger (IAC) therapy may counteract this factor, ultimately providing some protection after acute phase renal I/R injury. The aim of this preliminary study was to assess the ability of IAC to reduce acute kidney injury in C57BL/6 mice after 30-minute of bilateral ischemia followed by reperfusion. The rise in serum creatinine level was higher in C57BL/6 control mice after I/R when compared to IAC (1 mg)-treated mice. Control mice showed greater body weight loss compared to IAC-treated mice, and at pathology, reduced signs of tubular necrosis were also evident in IAC-treated mice. These preliminary evidences lay the basis for more comprehensive studies on the positive effects of IAC as a complementary therapeutic approach for acute phase renal I/R injury.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalSpringerPlus
Volume3
Issue number1
DOIs
Publication statusPublished - 2014

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Keywords

  • Inflammation
  • Ischemia/reperfusion
  • Kidney disease
  • Kidney transplantation
  • Radical oxygen species

ASJC Scopus subject areas

  • General

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