TY - JOUR
T1 - Positive effects on hematopoiesis in patients with myelodysplastic syndrome receiving deferasirox as oral iron chelation therapy
T2 - A brief review
AU - Guariglia, Roberto
AU - Martorelli, Maria Carmen
AU - Villani, Oreste
AU - Pietrantuono, Giuseppe
AU - Mansueto, Giovanna
AU - D'Auria, Fiorella
AU - Grieco, Vitina
AU - Bianchino, Gabriella
AU - Lerose, Rosa
AU - Bochicchio, Giovanni Battista
AU - Musto, Pellegrino
PY - 2011/5
Y1 - 2011/5
N2 - Iron overload is a frequent consequence in transfusion-dependent myelodysplastic syndromes (MDSs), which often requires iron chelation therapy (ICT). Interestingly, ICT may sometimes induce a hematologic improvement that leads to significant reduction or complete interruption of blood transfusions. This phenomenon has been recently described in MDS treated with the new oral chelator deferasirox.Here we briefly review the literature about this phenomenon and discuss the possible biological mechanisms underlying hematologic effects of deferasirox in MDS, starting from a new paradigmatic case in whom both hemoglobin level and platelet count improved, inducing transfusion-independence, soon after starting the treatment with deferasirox.
AB - Iron overload is a frequent consequence in transfusion-dependent myelodysplastic syndromes (MDSs), which often requires iron chelation therapy (ICT). Interestingly, ICT may sometimes induce a hematologic improvement that leads to significant reduction or complete interruption of blood transfusions. This phenomenon has been recently described in MDS treated with the new oral chelator deferasirox.Here we briefly review the literature about this phenomenon and discuss the possible biological mechanisms underlying hematologic effects of deferasirox in MDS, starting from a new paradigmatic case in whom both hemoglobin level and platelet count improved, inducing transfusion-independence, soon after starting the treatment with deferasirox.
KW - Deferasirox
KW - Hemopoietic improvement
KW - Iron chelation
KW - Myelodysplastic syndromes
KW - Transfusion dependence
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U2 - 10.1016/j.leukres.2010.11.027
DO - 10.1016/j.leukres.2010.11.027
M3 - Article
C2 - 21185078
AN - SCOPUS:79954569782
VL - 35
SP - 566
EP - 570
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 5
ER -