Positive emotional arousal increases duration of memory traces: Different role of dopamine D1 receptor and β-adrenoceptor activation

D. Conversi, F. Cruciani, A. Accoto, S. Cabib

Research output: Contribution to journalArticle

Abstract

We investigated the effects of post-training administration of dopamine D1 receptor antagonist SCH 23390 and β-adrenergic receptor antagonist Propranolol on memory retention of an object sampled in a state of positive emotional arousal. Saline-treated mice trained and tested under high emotional/motivational arousal (High) showed discrimination of a novel object both 24 and 96 h post-training. Instead, mice trained and tested under low motivational arousal (Low) were unable to discriminate the novel object 96 h post-training. Both a high (2 mg/kg) and a low (1 mg/kg) dose of Propranolol reduced object discrimination in High mice tested 24 h post-training, whereas neither dose was effective in Low mice. A high dose of SCH 23390 (0.025 mg/kg) reduced discrimination of the novel object in High mice tested both 24 and 96 h post-training, whereas a low dose of the D1 antagonist (0.01 mg/kg) reduced discrimination in High mice tested 96 h post-training and abolished discrimination in Low mice tested 24 h after training.

Original languageEnglish
Pages (from-to)158-163
Number of pages6
JournalPharmacology, Biochemistry and Behavior
Volume122
DOIs
Publication statusPublished - 2014

Fingerprint

Dopamine D1 Receptors
Arousal
Propranolol
Adrenergic Receptors
Chemical activation
Data storage equipment
Adrenergic Antagonists
Dopamine Antagonists
SCH 23390
Discrimination (Psychology)

Keywords

  • Beta-adrenoceptors
  • Emotional arousal
  • Long-term memory
  • Object recognition
  • Propranolol
  • SCH 23390

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Pharmacology
  • Toxicology
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Medicine(all)

Cite this

Positive emotional arousal increases duration of memory traces : Different role of dopamine D1 receptor and β-adrenoceptor activation. / Conversi, D.; Cruciani, F.; Accoto, A.; Cabib, S.

In: Pharmacology, Biochemistry and Behavior, Vol. 122, 2014, p. 158-163.

Research output: Contribution to journalArticle

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