Positive experience of intraperitoneal chemotherapy followed by intravenous chemotherapy in heavily pretreated patients with suboptimal residual ovarian cancer and primary peritoneal cancer

Maria Ornella Nicoletto, Maurizia Dalla Palma, Martin E. Donach, Milena Gusella, Alessandro Cappetta, Malihe Shams, Aberto Marchet, Margherita Nardin, Giovanna Pintacuda, Antonio Di Maggio, Maddalena Marchesi, Paolo Carli, Pasquale Fiduccia, Grazia Artioli, Donato Nitti

Research output: Contribution to journalArticle

Abstract

Aims and background. To assess feasibility and toxicity of intraperitoneal administration of cisplatin and paclitaxel, followed by intravenous chemotherapy in pretreated patients with suboptimal ovarian cancer (residuum >1 cm) or primary peritoneal tumor, and suffering from ascites and/or intestinal obstruction. Methods. Fourteen relapsed ovarian cancer patients, 5 of whom were platinum sensitive (platinum-free interval >6 mo), 7 platinum-resistant (platinum-free interval >6 mo), and 2 platinum-refractory, received one cycle of intraperitoneal cisplatin, 100 mg/m2 on day 1, and two cycles of intraperitoneal paclitaxel, 120 mg/m2 on days 8 and 14. Intravenous chemotherapy was administrated 4 weeks following the last intraperitoneal paclitaxel instillation. Blood and peritoneal fluid samples were harvested at 0, 1, 4 and 24 h after ending paclitaxel delivery to guarantee proper tumor exposure and patient safety. Results. Intraperitoneal cisplatin determined 6 cases of vomiting grade 1-2 (40% of the morbidity). Intraperitoneal paclitaxel was associated with 6 events of grade 1-2 abdominal pain; the only grade 4 toxicity was one case of neutropenia and one ofmucositis. Ascites decreased in 11 patients: the median time to first need for paracentesis was 5 months, compared to a median baseline paracentesis of 4 weeks. Three intestinal normalizations were obtained. Themedian overall survival was 10 months for our cohort of patients. Intraperitoneal paclitaxel clearance was significantly higher in patients with suboptimal tumor and symptomatic disease than in patients with smaller residual masses and without ascites (P = 0.004). Conclusions. Intraperitoneal treatment was feasible, and enhanced response to the following intravenous chemotherapy was seen in these patients. Free full text available at www.tumorionline.it.

Original languageEnglish
Pages (from-to)918-925
Number of pages8
JournalTumori
Volume96
Issue number6
Publication statusPublished - Nov 2010

Keywords

  • Placlitaxel
  • Platinum-resistant patients
  • Platinum-sensitive patients
  • Taxol

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Nicoletto, M. O., Palma, M. D., Donach, M. E., Gusella, M., Cappetta, A., Shams, M., Marchet, A., Nardin, M., Pintacuda, G., Di Maggio, A., Marchesi, M., Carli, P., Fiduccia, P., Artioli, G., & Nitti, D. (2010). Positive experience of intraperitoneal chemotherapy followed by intravenous chemotherapy in heavily pretreated patients with suboptimal residual ovarian cancer and primary peritoneal cancer. Tumori, 96(6), 918-925.