Positive glucose breath testing is more prevalent in patients with IBS-like symptoms compared with controls of similar age and gender distribution

Andrea Parodi, Pietro Dulbecco, Edoardo Savarino, Edoardo Giovanni Giannini, Giorgia Bodini, Marina Corbo, Luca Isola, Stefano De Conca, Elisa Marabotto, Vincenzo Savarino

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Small intestinal bacterial overgrowth (SIBO) may mimic a functional disorder such as irritable bowel syndrome (IBS) or functional bloating (FB). In this study, we aimed to assess the utility of glucose breath test (GBT) in patients with the above conditions. Methods: This study included 200 consecutive patients (130 with IBS and 70 with FB on the basis of Rome III criteria) and 70 controls with similar age and sex distribution. Patients and controls underwent 50 g GBT and a H2 peak of ≥12 ppm was considered diagnostic of SIBO. Positive patients received rifaximin of 1200mg/day for 10 days and underwent a second GBT 1 month after the end of treatment. A symptom questionnaire was completed before and after therapy. Results: GBT resulted to be altered in 21 out of 130 IBS patients and in 2 out of 70 FB patients with a significant difference of the former group compared with controls (3 out of 70, P=0.0137). Most IBS patients with a positive GBT complained of diarrhea. GBT showed an increased methane excretion in 26% of patients, who were equally distributed among different bowel pattern subgroups. Previous abdominal surgery was more frequently seen in GBT-positive patients (P=0.008). After antibiotic treatment, eradication of SIBO was achieved in 70% of patients, with a significant improvement of symptoms in eradicated patients compared with the not eradicated ones (P

Original languageEnglish
Pages (from-to)962-966
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume43
Issue number10
DOIs
Publication statusPublished - Nov 2009

Keywords

  • Functional bloating
  • Glucose breath test
  • Irritable bowel syndrome
  • Small intestinal bacterial overgrowth

ASJC Scopus subject areas

  • Gastroenterology

Fingerprint Dive into the research topics of 'Positive glucose breath testing is more prevalent in patients with IBS-like symptoms compared with controls of similar age and gender distribution'. Together they form a unique fingerprint.

Cite this