Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study

Vipul R. Patel; Rafael F. Coelho; Bernardo Rocco; Marcelo Orvieto; Ananthakrishnan Sivaraman; Kenneth J. Palmer; Darien Kameh; Luigi Santoro; Geoff D. Coughlin; Michael Liss; Wooju Jeong; John Malcolm; Joshua M. Stern; Saurabh Sharma; Kevin C. Zorn; Sergey Shikanov; Arieh L. Shalhav; Gregory P. Zagaja; Thomas E. Ahlering; Koon H. Rha; David M. Albala; Michael D. Fabrizio; David I. Lee; Sanket Chauhan

doi:10.1016/j.juro.2011.03.112

Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study

Vipul R. Patel, Rafael F. Coelho, Bernardo Rocco, Marcelo Orvieto, Ananthakrishnan Sivaraman, Kenneth J. Palmer, Darien Kameh, Luigi Santoro, Geoff D. Coughlin, Michael Liss, Wooju Jeong, John Malcolm, Joshua M. Stern, Saurabh Sharma, Kevin C. Zorn, Sergey Shikanov, Arieh L. Shalhav, Gregory P. Zagaja, Thomas E. Ahlering, Koon H. RhaDavid M. Albala, Michael D. Fabrizio, David I. Lee, Sanket Chauhan

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: Positive surgical margins are an independent predictive factor for biochemical recurrence after radical prostatectomy. We analyzed the incidence of and associative factors for positive surgical margins in a multi-institutional series of 8,418 robotic assisted radical prostatectomies. Materials and Methods: We analyzed the records of 8,418 patients who underwent robotic assisted radical prostatectomy at 7 institutions. Of the patients 323 had missing data on margin status. Positive surgical margins were categorized into 4 groups, including apex, bladder neck, posterolateral and multifocal. The records of 6,169 patients were available for multivariate analysis. The variables entered into the logistic regression models were age, body mass index, preoperative prostate specific antigen, biopsy Gleason score, prostate weight and pathological stage. A second model was built to identify predictive factors for positive surgical margins in the subset of patients with organ confined disease (pT2). Results: The overall positive surgical margin rate was 15.7% (1,272 of 8,095 patients). The positive surgical margin rate for pT2 and pT3 disease was 9.45% and 37.2%, respectively. On multivariate analysis pathological stage (pT2 vs pT3 OR 4.588, p

Original language	English
Pages (from-to)	511-516
Number of pages	6
Journal	Journal of Urology
Volume	186
Issue number	2
DOIs	https://doi.org/10.1016/j.juro.2011.03.112
Publication status	Published - Aug 2011

Keywords

local
neoplasm recurrence
prostate
prostatectomy
prostatic neoplasms
robotics

ASJC Scopus subject areas

Urology

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Patel, V. R., Coelho, R. F., Rocco, B., Orvieto, M., Sivaraman, A., Palmer, K. J., Kameh, D., Santoro, L., Coughlin, G. D., Liss, M., Jeong, W., Malcolm, J., Stern, J. M., Sharma, S., Zorn, K. C., Shikanov, S., Shalhav, A. L., Zagaja, G. P., Ahlering, T. E., ... Chauhan, S. (2011). Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study. Journal of Urology, 186(2), 511-516. https://doi.org/10.1016/j.juro.2011.03.112

Positive surgical margins after robotic assisted radical prostatectomy : A multi-institutional study. / Patel, Vipul R.; Coelho, Rafael F.; Rocco, Bernardo; Orvieto, Marcelo; Sivaraman, Ananthakrishnan; Palmer, Kenneth J.; Kameh, Darien; Santoro, Luigi; Coughlin, Geoff D.; Liss, Michael; Jeong, Wooju; Malcolm, John; Stern, Joshua M.; Sharma, Saurabh; Zorn, Kevin C.; Shikanov, Sergey; Shalhav, Arieh L.; Zagaja, Gregory P.; Ahlering, Thomas E.; Rha, Koon H.; Albala, David M.; Fabrizio, Michael D.; Lee, David I.; Chauhan, Sanket.

In: Journal of Urology, Vol. 186, No. 2, 08.2011, p. 511-516.

Research output: Contribution to journal › Article › peer-review

Patel, VR, Coelho, RF, Rocco, B, Orvieto, M, Sivaraman, A, Palmer, KJ, Kameh, D, Santoro, L, Coughlin, GD, Liss, M, Jeong, W, Malcolm, J, Stern, JM, Sharma, S, Zorn, KC, Shikanov, S, Shalhav, AL, Zagaja, GP, Ahlering, TE, Rha, KH, Albala, DM, Fabrizio, MD, Lee, DI & Chauhan, S 2011, 'Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study', Journal of Urology, vol. 186, no. 2, pp. 511-516. https://doi.org/10.1016/j.juro.2011.03.112

Patel, Vipul R. ; Coelho, Rafael F. ; Rocco, Bernardo ; Orvieto, Marcelo ; Sivaraman, Ananthakrishnan ; Palmer, Kenneth J. ; Kameh, Darien ; Santoro, Luigi ; Coughlin, Geoff D. ; Liss, Michael ; Jeong, Wooju ; Malcolm, John ; Stern, Joshua M. ; Sharma, Saurabh ; Zorn, Kevin C. ; Shikanov, Sergey ; Shalhav, Arieh L. ; Zagaja, Gregory P. ; Ahlering, Thomas E. ; Rha, Koon H. ; Albala, David M. ; Fabrizio, Michael D. ; Lee, David I. ; Chauhan, Sanket. / Positive surgical margins after robotic assisted radical prostatectomy : A multi-institutional study. In: Journal of Urology. 2011 ; Vol. 186, No. 2. pp. 511-516.

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title = "Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study",

abstract = "Purpose: Positive surgical margins are an independent predictive factor for biochemical recurrence after radical prostatectomy. We analyzed the incidence of and associative factors for positive surgical margins in a multi-institutional series of 8,418 robotic assisted radical prostatectomies. Materials and Methods: We analyzed the records of 8,418 patients who underwent robotic assisted radical prostatectomy at 7 institutions. Of the patients 323 had missing data on margin status. Positive surgical margins were categorized into 4 groups, including apex, bladder neck, posterolateral and multifocal. The records of 6,169 patients were available for multivariate analysis. The variables entered into the logistic regression models were age, body mass index, preoperative prostate specific antigen, biopsy Gleason score, prostate weight and pathological stage. A second model was built to identify predictive factors for positive surgical margins in the subset of patients with organ confined disease (pT2). Results: The overall positive surgical margin rate was 15.7% (1,272 of 8,095 patients). The positive surgical margin rate for pT2 and pT3 disease was 9.45% and 37.2%, respectively. On multivariate analysis pathological stage (pT2 vs pT3 OR 4.588, p ",

keywords = "local, neoplasm recurrence, prostate, prostatectomy, prostatic neoplasms, robotics",

author = "Patel, {Vipul R.} and Coelho, {Rafael F.} and Bernardo Rocco and Marcelo Orvieto and Ananthakrishnan Sivaraman and Palmer, {Kenneth J.} and Darien Kameh and Luigi Santoro and Coughlin, {Geoff D.} and Michael Liss and Wooju Jeong and John Malcolm and Stern, {Joshua M.} and Saurabh Sharma and Zorn, {Kevin C.} and Sergey Shikanov and Shalhav, {Arieh L.} and Zagaja, {Gregory P.} and Ahlering, {Thomas E.} and Rha, {Koon H.} and Albala, {David M.} and Fabrizio, {Michael D.} and Lee, {David I.} and Sanket Chauhan",

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AU - Patel, Vipul R.

AU - Coelho, Rafael F.

AU - Rocco, Bernardo

AU - Orvieto, Marcelo

AU - Sivaraman, Ananthakrishnan

AU - Palmer, Kenneth J.

AU - Kameh, Darien

AU - Santoro, Luigi

AU - Coughlin, Geoff D.

AU - Liss, Michael

AU - Jeong, Wooju

AU - Malcolm, John

AU - Stern, Joshua M.

AU - Sharma, Saurabh

AU - Zorn, Kevin C.

AU - Shikanov, Sergey

AU - Shalhav, Arieh L.

AU - Zagaja, Gregory P.

AU - Ahlering, Thomas E.

AU - Rha, Koon H.

AU - Albala, David M.

AU - Fabrizio, Michael D.

AU - Lee, David I.

AU - Chauhan, Sanket

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N2 - Purpose: Positive surgical margins are an independent predictive factor for biochemical recurrence after radical prostatectomy. We analyzed the incidence of and associative factors for positive surgical margins in a multi-institutional series of 8,418 robotic assisted radical prostatectomies. Materials and Methods: We analyzed the records of 8,418 patients who underwent robotic assisted radical prostatectomy at 7 institutions. Of the patients 323 had missing data on margin status. Positive surgical margins were categorized into 4 groups, including apex, bladder neck, posterolateral and multifocal. The records of 6,169 patients were available for multivariate analysis. The variables entered into the logistic regression models were age, body mass index, preoperative prostate specific antigen, biopsy Gleason score, prostate weight and pathological stage. A second model was built to identify predictive factors for positive surgical margins in the subset of patients with organ confined disease (pT2). Results: The overall positive surgical margin rate was 15.7% (1,272 of 8,095 patients). The positive surgical margin rate for pT2 and pT3 disease was 9.45% and 37.2%, respectively. On multivariate analysis pathological stage (pT2 vs pT3 OR 4.588, p

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Positive surgical margins after robotic assisted radical prostatectomy: A multi-institutional study

Abstract

Keywords

ASJC Scopus subject areas

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