Positron emission tomography for the detection of colorectal adenomas

Davide Ravizza, Mirco Bartolomei, Luigi Santoro, Darina Tamayo, Giancarla Fiori, Cristina Trovato, Concetta De Cicco, Giuseppe De Roberto, Giovanni Paganelli, Cristiano Crosta

Research output: Contribution to journalArticlepeer-review


Background: 18F-fluorodeoxyglucose ( 18F-FDG) positron emission tomography (PET) has been reported to detect colorectal adenomas. Aims: This study aimed at evaluating the sensitivity of 18F-FDG PET with computed tomography image fusion (PET/CT) for detecting colorectal adenomas. Methods: We retrospectively compared the results of 92 18F-FDG PET/CT studies followed by colonoscopy. Colonoscopy and histology were considered as the gold standard. Results: One hundred fifty-seven lesions were observed. All the 12 malignancies were identified by 18F-FDG PET/CT but only 27 out of 119 resected adenomas (sensitivity 22.7%) and none of the hyperplastic polyps were detected. At the univariate and multivariate analyses there was a significant statistical association between adenomas sized more than 10 mm, presence of villous component and high-grade dysplasia and the ability of 18F-FDG PET/CT to detect adenomas. 18F-FDG PET/CT showed an overall sensitivity of 29.8%, a specificity of 81.1%, a positive predictive value (PPV) of 84.8% and a negative predictive value (NPV) of 24.6% for the neoplastic colorectal lesions globally considered. Conclusion: 18F-FDG PET/CT has a low sensitivity for detecting adenomas. However, because of the specificity and PPV of the technique for neoplastic colorectal lesions, the presence of a focal colorectal FDG uptake justifies the patient undergoing colonoscopy.

Original languageEnglish
Pages (from-to)185-190
Number of pages6
JournalDigestive and Liver Disease
Issue number3
Publication statusPublished - Mar 2010


  • F-fluorodeoxyglucose positron emission tomography
  • Colonic adenoma
  • Colonic neoplasm
  • PET/CT

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology


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