Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

I. Günther; M. Psylla; G. N. Reddy; A. Antonini; P. Vontobel; H. W. Reist; A. Zollinger; R. J. Nickles; H. F. Beer; P. A. Schubiger; K. L. Leenders

doi:10.1016/0969-8051(95)00032-S

Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

I. Günther, M. Psylla, G. N. Reddy, A. Antonini, P. Vontobel, H. W. Reist, A. Zollinger, R. J. Nickles, H. F. Beer, P. A. Schubiger, K. L. Leenders

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[¹⁸F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.

Original language	English
Pages (from-to)	921-927
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/0969-8051(95)00032-S
Publication status	Published - 1995

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

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Günther, I., Psylla, M., Reddy, G. N., Antonini, A., Vontobel, P., Reist, H. W., Zollinger, A., Nickles, R. J., Beer, H. F., Schubiger, P. A., & Leenders, K. L. (1995). Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey. Nuclear Medicine and Biology, 22(7), 921-927. https://doi.org/10.1016/0969-8051(95)00032-S

Günther, I, Psylla, M, Reddy, GN, Antonini, A, Vontobel, P, Reist, HW, Zollinger, A, Nickles, RJ, Beer, HF, Schubiger, PA & Leenders, KL 1995, 'Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey', Nuclear Medicine and Biology, vol. 22, no. 7, pp. 921-927. https://doi.org/10.1016/0969-8051(95)00032-S

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abstract = "We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.",

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AU - Günther, I.

AU - Psylla, M.

AU - Reddy, G. N.

AU - Antonini, A.

AU - Vontobel, P.

AU - Reist, H. W.

AU - Zollinger, A.

AU - Nickles, R. J.

AU - Beer, H. F.

AU - Schubiger, P. A.

AU - Leenders, K. L.

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Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

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