Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

I. Günther, M. Psylla, G. N. Reddy, A. Antonini, P. Vontobel, H. W. Reist, A. Zollinger, R. J. Nickles, H. F. Beer, P. A. Schubiger, K. L. Leenders

Research output: Contribution to journalArticlepeer-review

Abstract

We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.

Original languageEnglish
Pages (from-to)921-927
Number of pages7
JournalNuclear Medicine and Biology
Volume22
Issue number7
DOIs
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

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