Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

I. Günther; M. Psylla; G. N. Reddy; A. Antonini; P. Vontobel; H. W. Reist; A. Zollinger; R. J. Nickles; H. F. Beer; P. A. Schubiger; K. L. Leenders

doi:10.1016/0969-8051(95)00032-S

Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

I. Günther, M. Psylla, G. N. Reddy, A. Antonini, P. Vontobel, H. W. Reist, A. Zollinger, R. J. Nickles, H. F. Beer, P. A. Schubiger, K. L. Leenders

Istituto di Neuroriabilitazione Motoria San Camillo

Research output: Contribution to journal › Article › peer-review

Abstract

We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[¹⁸F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.

Original language	English
Pages (from-to)	921-927
Number of pages	7
Journal	Nuclear Medicine and Biology
Volume	22
Issue number	7
DOIs	https://doi.org/10.1016/0969-8051(95)00032-S
Publication status	Published - 1995

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/0969-8051(95)00032-S

Cite this

Günther, I., Psylla, M., Reddy, G. N., Antonini, A., Vontobel, P., Reist, H. W., Zollinger, A., Nickles, R. J., Beer, H. F., Schubiger, P. A., & Leenders, K. L. (1995). Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey. Nuclear Medicine and Biology, 22(7), 921-927. https://doi.org/10.1016/0969-8051(95)00032-S

Positron emission tomography in drug evaluation : Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey. / Günther, I.; Psylla, M.; Reddy, G. N.; Antonini, A.; Vontobel, P.; Reist, H. W.; Zollinger, A.; Nickles, R. J.; Beer, H. F.; Schubiger, P. A.; Leenders, K. L.

In: Nuclear Medicine and Biology, Vol. 22, No. 7, 1995, p. 921-927.

Research output: Contribution to journal › Article › peer-review

Günther, I, Psylla, M, Reddy, GN, Antonini, A, Vontobel, P, Reist, HW, Zollinger, A, Nickles, RJ, Beer, HF, Schubiger, PA & Leenders, KL 1995, 'Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey', Nuclear Medicine and Biology, vol. 22, no. 7, pp. 921-927. https://doi.org/10.1016/0969-8051(95)00032-S

Günther, I. ; Psylla, M. ; Reddy, G. N. ; Antonini, A. ; Vontobel, P. ; Reist, H. W. ; Zollinger, A. ; Nickles, R. J. ; Beer, H. F. ; Schubiger, P. A. ; Leenders, K. L. / Positron emission tomography in drug evaluation : Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey. In: Nuclear Medicine and Biology. 1995 ; Vol. 22, No. 7. pp. 921-927.

@article{2c94b440d07544ce80c66a71e41cf0a2,

title = "Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey",

abstract = "We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.",

author = "I. G{\"u}nther and M. Psylla and Reddy, {G. N.} and A. Antonini and P. Vontobel and Reist, {H. W.} and A. Zollinger and Nickles, {R. J.} and Beer, {H. F.} and Schubiger, {P. A.} and Leenders, {K. L.}",

year = "1995",

doi = "10.1016/0969-8051(95)00032-S",

language = "English",

volume = "22",

pages = "921--927",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

publisher = "Elsevier Inc.",

number = "7",

}

TY - JOUR

T1 - Positron emission tomography in drug evaluation

T2 - Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

AU - Günther, I.

AU - Psylla, M.

AU - Reddy, G. N.

AU - Antonini, A.

AU - Vontobel, P.

AU - Reist, H. W.

AU - Zollinger, A.

AU - Nickles, R. J.

AU - Beer, H. F.

AU - Schubiger, P. A.

AU - Leenders, K. L.

PY - 1995

Y1 - 1995

N2 - We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.

AB - We compared the influence of three different catechol-O-methyltransferase (COMT) inhibitors (CGP 28014, OR-611 and Ro 40-7592) on the metabolism of no-carrier-added (NCA) 6-[18F]fluoro-l-dopa (6-FDOPA) in one Rhesus monkey. All three COMT inhibitors improved 6-FDOPA availability in plasma, increased the specific uptake in the brain and thus improved 6-FDOPA uptake measurements using positron emission tomography (PET). Best results were obtained with Ro 40-7592.

UR - http://www.scopus.com/inward/record.url?scp=0028862753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028862753&partnerID=8YFLogxK

U2 - 10.1016/0969-8051(95)00032-S

DO - 10.1016/0969-8051(95)00032-S

M3 - Article

C2 - 8547890

AN - SCOPUS:0028862753

VL - 22

SP - 921

EP - 927

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 7

ER -

Positron emission tomography in drug evaluation: Influence of three different catechol-O-methyltransferase inhibitors on metabolism of [NCA] 6-[18F]fluoro-l-dopa in rhesus monkey

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this