Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi

Luigi Rigacci, Umberto Vitolo, Luca Nassi, Francesco Merli, Andrea Gallamini, Patrizia Pregno, Isabel Alvarez, Flavia Salvi, Rosaria Sancetta, Antonio Castagnoli, Annibale Versari, Alberto Biggi, Michele Gregianin, Ettore Pelosi, Teodoro Chisesi, Alberto Bosi, Alessandro Levis

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Abstract

In this prospective multicentric study, we investigated the contribution of positron emission tomography (PET) scanning to the staging of Hodgkin's lymphoma (HL) by computed tomography (CT) and attempted to determine whether it has any impact on therapeutic approach. One hundred eighty six consecutive patients with HL from six Italian centers were enrolled in this study. They were staged with conventional methods; 2-[fluorine-18]fluoro-2-deoxy-D-glucose PET scanning were prospectively compared to CT. CT and FDG-PET stages were concordant in 156 patients (84%) and discordant in 30 patients (16%). PET stage in comparison to CT stage was higher in 27 patients (14%) and lower in 3 patients (1%). The programmed treatment strategy was modified in 11 out of 30 patients (37%) after the definition of final stage. If we considered the 123 CT staged patients with localized stage, ten patients (8%) with a change of stage from localized to advanced after PET evaluation were treated with different strategy. FDG-PET was shown to be a relevant, noninvasive method that supplements conventional procedures and should therefore be used routinely to stage HL, particularly in early stage patients, where a change in stage may modify disease management.

Original languageEnglish
Pages (from-to)897-903
Number of pages7
JournalAnnals of Hematology
Volume86
Issue number12
DOIs
Publication statusPublished - 2007

Fingerprint

Hodgkin Disease
Positron-Emission Tomography
Prospective Studies
Tomography
Fluorine
Deoxyglucose
Disease Management
Therapeutics

Keywords

  • Computed tomography
  • FDG-PET
  • Hodgkin's disease
  • Staging

ASJC Scopus subject areas

  • Hematology

Cite this

Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi. / Rigacci, Luigi; Vitolo, Umberto; Nassi, Luca; Merli, Francesco; Gallamini, Andrea; Pregno, Patrizia; Alvarez, Isabel; Salvi, Flavia; Sancetta, Rosaria; Castagnoli, Antonio; Versari, Annibale; Biggi, Alberto; Gregianin, Michele; Pelosi, Ettore; Chisesi, Teodoro; Bosi, Alberto; Levis, Alessandro.

In: Annals of Hematology, Vol. 86, No. 12, 2007, p. 897-903.

Research output: Contribution to journalArticle

Rigacci, L, Vitolo, U, Nassi, L, Merli, F, Gallamini, A, Pregno, P, Alvarez, I, Salvi, F, Sancetta, R, Castagnoli, A, Versari, A, Biggi, A, Gregianin, M, Pelosi, E, Chisesi, T, Bosi, A & Levis, A 2007, 'Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi', Annals of Hematology, vol. 86, no. 12, pp. 897-903. https://doi.org/10.1007/s00277-007-0356-9
Rigacci, Luigi ; Vitolo, Umberto ; Nassi, Luca ; Merli, Francesco ; Gallamini, Andrea ; Pregno, Patrizia ; Alvarez, Isabel ; Salvi, Flavia ; Sancetta, Rosaria ; Castagnoli, Antonio ; Versari, Annibale ; Biggi, Alberto ; Gregianin, Michele ; Pelosi, Ettore ; Chisesi, Teodoro ; Bosi, Alberto ; Levis, Alessandro. / Positron emission tomography in the staging of patients with Hodgkin's lymphoma. A prospective multicentric study by the Intergruppo Italiano Linfomi. In: Annals of Hematology. 2007 ; Vol. 86, No. 12. pp. 897-903.
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