Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 1

Pierpaolo Alongi, Riccardo Laudicella, Isacco Desideri, Agostino Chiaravalloti, Paolo Borghetti, Natale Quartuccio, Michele Fiore, Laura Evangelista, Lorenza Marino, Federico Caobelli, Carmelo Tuscano, Paola Mapelli, Valentina Lancellotta, Salvatore Annunziata, Maria Ricci, Elisa Ciurlia, Alba Fiorentino

Research output: Contribution to journalReview article

Abstract

AIM: Functional and molecular imaging, including positron emission tomography with computed tomography imaging (PET/CT) is increasing for radiotherapy (RT) definition of the target volume. This expert review summarizes existing data of functional imaging modalities and RT management, in terms of target volume delineation, for the following anatomical districts: brain (for primary and secondary tumors), head/neck and lung.

MATERIALS AND METHODS: A collection of available published data was made, by PubMed a search. Only original articles were carefully and critically revised.

RESULTS: For primary and secondary brain tumors, amino acid PET radiotracers could be useful to identify microscopic residual areas and to differ between recurrence and treatment-related alterations in case of re-irradiation. As for head and neck neoplasms may benefit from precise PET/CT-based target delineation, due to the major capability to identify high-risk RT areas. In primary and secondary lung cancer, PET/CT could be useful both to delimit a tumor and collapsed lungs and as a predictive parameter of treatment response.

CONCLUSION: Taken together, molecular and functional imaging approaches offer a major step to individualize radiotherapeutic care going forward. Nevertheless, several uncertainties remain on the standard method to properly assess the target volume definition including PET information for primary and secondary brain tumors.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
JournalCritical Reviews in Oncology/Hematology
Volume140
DOIs
Publication statusPublished - Aug 2019

Keywords

  • Brain Neoplasms/diagnostic imaging
  • Head and Neck Neoplasms/diagnostic imaging
  • Humans
  • Lung Neoplasms/diagnostic imaging
  • Positron Emission Tomography Computed Tomography/methods
  • Practice Guidelines as Topic
  • Radiotherapy Planning, Computer-Assisted/methods

Fingerprint Dive into the research topics of 'Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 1'. Together they form a unique fingerprint.

  • Cite this

    Alongi, P., Laudicella, R., Desideri, I., Chiaravalloti, A., Borghetti, P., Quartuccio, N., Fiore, M., Evangelista, L., Marino, L., Caobelli, F., Tuscano, C., Mapelli, P., Lancellotta, V., Annunziata, S., Ricci, M., Ciurlia, E., & Fiorentino, A. (2019). Positron emission tomography with computed tomography imaging (PET/CT) for the radiotherapy planning definition of the biological target volume: PART 1. Critical Reviews in Oncology/Hematology, 140, 74-79. https://doi.org/10.1016/j.critrevonc.2019.01.011