Possibile attivazione di contatto della prorenina umana con la membrana cellulare.

Translated title of the contribution: Possible activation of human prorenin by contact with the cell membrane

C. Troffa, G. Tonolo, P. Manunta, A. Pazzola, M. G. Melis, F. Pala, A. Soro, P. Madeddu, N. Glorioso

Research output: Contribution to journalArticlepeer-review

Abstract

Semipurified human kidney prorenin was exposed in vitro to a mixture of lipids mimicking the composition of the inner leaflet of the cell membrane, in the presence of semipurified human angiotensinogen at a concentration of 1/4 Km. Prorenin was activated in a time-dependent manner over a period of 60 min. This lipid-dependent activation was completely reversed thereafter. Pre-incubation with anti-renin serum completely prevented this activated prorenin-dependent generation of angiotensin I. Our data suggest that human prorenin can be reversibly activated by contact with the cell membrane.

Translated title of the contributionPossible activation of human prorenin by contact with the cell membrane
Original languageItalian
Pages (from-to)1017-1023
Number of pages7
JournalBollettino della Societa Italiana di Biologia Sperimentale
Volume65
Issue number11
Publication statusPublished - Nov 1989

ASJC Scopus subject areas

  • Medicine(all)

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