Possible autoantibody-negative limbic encephalitis after anterior temporal lobectomy for hippocampal sclerosis

Research output: Contribution to journalArticle

Abstract

Purpose: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. Materials and methods: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures. Results: A diagnosis of a possible autoimmune encephalitis was made. Conclusions: Due to its peculiarities (compared with other cases of bilateral temporal lesions, the damage occurred on two distinct occasions), this case might contribute to shed light on the issue of the possible contralateral reorganization of memory processes subserved by the mesial temporal lobe structures chronically involved in epileptogenesis.

Original languageEnglish
Pages (from-to)464-466
Number of pages3
JournalInternational Journal of Neuroscience
Volume128
Issue number5
DOIs
Publication statusPublished - May 1 2018

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Anterior Temporal Lobectomy
Limbic Encephalitis
Sclerosis
Temporal Lobe
Autoantibodies
Amnesia
Temporal Lobe Epilepsy
Neuroimaging
Seizures

Keywords

  • anterior temporal lobectomy
  • global amnesia
  • limbic encephalitis
  • memory
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Possible autoantibody-negative limbic encephalitis after anterior temporal lobectomy for hippocampal sclerosis",
abstract = "Purpose: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. Materials and methods: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures. Results: A diagnosis of a possible autoimmune encephalitis was made. Conclusions: Due to its peculiarities (compared with other cases of bilateral temporal lesions, the damage occurred on two distinct occasions), this case might contribute to shed light on the issue of the possible contralateral reorganization of memory processes subserved by the mesial temporal lobe structures chronically involved in epileptogenesis.",
keywords = "anterior temporal lobectomy, global amnesia, limbic encephalitis, memory, Temporal lobe epilepsy",
author = "Sara Casciato and Alfredo D'Aniello and Addolorata Mascia and Quarato, {Pier Paolo} and {De Risi}, Marco and Grammaldo, {Liliana G.} and Vincenzo Esposito and Marco Zoccarato and {Di Gennaro}, Giancarlo",
year = "2018",
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language = "English",
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journal = "International Journal of Neuroscience",
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TY - JOUR

T1 - Possible autoantibody-negative limbic encephalitis after anterior temporal lobectomy for hippocampal sclerosis

AU - Casciato, Sara

AU - D'Aniello, Alfredo

AU - Mascia, Addolorata

AU - Quarato, Pier Paolo

AU - De Risi, Marco

AU - Grammaldo, Liliana G.

AU - Esposito, Vincenzo

AU - Zoccarato, Marco

AU - Di Gennaro, Giancarlo

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Purpose: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. Materials and methods: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures. Results: A diagnosis of a possible autoimmune encephalitis was made. Conclusions: Due to its peculiarities (compared with other cases of bilateral temporal lesions, the damage occurred on two distinct occasions), this case might contribute to shed light on the issue of the possible contralateral reorganization of memory processes subserved by the mesial temporal lobe structures chronically involved in epileptogenesis.

AB - Purpose: Amnestic syndromes are acknowledged to be associated to bilateral hippocampal damage. Materials and methods: We briefly report the case of a young man who underwent anterior left temporal lobectomy for a medically refractory temporal lobe epilepsy due to hippocampal sclerosis with an excellent seizure and neuropsychological outcome. Approximately 10 years later, he presented with a subacute severe global amnesia and neuroimaging findings of a damage involving the contralateral mesial temporal lobe structures. Results: A diagnosis of a possible autoimmune encephalitis was made. Conclusions: Due to its peculiarities (compared with other cases of bilateral temporal lesions, the damage occurred on two distinct occasions), this case might contribute to shed light on the issue of the possible contralateral reorganization of memory processes subserved by the mesial temporal lobe structures chronically involved in epileptogenesis.

KW - anterior temporal lobectomy

KW - global amnesia

KW - limbic encephalitis

KW - memory

KW - Temporal lobe epilepsy

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JO - International Journal of Neuroscience

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