Correlazione tra reflusso gastroesofageo e fibrosi interstiziale polmonare in pazienti affetti da sclerosi sistemica

Translated title of the contribution: Possible connection between gastroesophageal reflux and interstitial pulmonary fibrosis in patients with systemic sclerosis

Edoardo Savarino, Massimo Ghio, Elisa Marabotto, Patrizia Zentilin, Giorgio Sammito, Giuseppe Cittadini, Luca Sconfienza, Carmelina Murolo, Lorenzo Gemignani, Francesco Indiveri, Vincenzo Savarino

Research output: Contribution to journalArticlepeer-review

Abstract

Interstitial lung disease represents the main cause of morbidity and mortality in patients with systemic sclerosis. The mechanisms leading to interstitial lung disease are poorly understood and thus current strategies have little effect on this progressive and fatal disease. Therefore, it appears relevant the importance to assess the possible risk factors involved in its pathogenesis. Previous studies in vivo and in vitro suggested that pulmonary fibrosis can occur after repeated aspiration of small amounts of gastric contents over long periods of time. Recently, our group observed that patients with systemic sclerosis and pulmonary fibrosis have a more severe degree of gastroesophageal reflux with a greater number of reflux events and a higher percentage of reflux episodes reaching the proximal esophagus, causing an increasing risk of microaspiration, compared to patients with systemic sclerosis without lung involvement. Further larger controlled studies are necessary to evaluate whether or not the development of interstitial lung disease in systemic sclerosis patients can be prevented by treating gastroesophageal reflux.

Translated title of the contributionPossible connection between gastroesophageal reflux and interstitial pulmonary fibrosis in patients with systemic sclerosis
Original languageItalian
Pages (from-to)512-516
Number of pages5
JournalRecenti Progressi in Medicina
Volume100
Issue number11
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Medicine(all)

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