Possible correlation between some biologic effects and the clinical course in patients treated with continuous infusion of interleukin-2 plus alpha-2 interferon for metastatic renal cell carcinoma

C. Baiocchi, G. Landonio, G. Balzarini, C. Cacioppo, M. Calgaro, M. Ferrari, O. Gottardi, M. Majno, F. Scanzi, E. Ghislandi, B. Brando

Research output: Contribution to journalArticle

Abstract

Background: Interleukin-2 therapy is known to cause many biologic effects, which are enhanced by the administration of interferon prior to or immediately after interleukin-2 infusion. Some of these effects could be related to the clinical response. Methods: Sixteen patients with metastatic renal cell carcinoma were treated with continuous infusion of interleukin-2 plus alpha-2 interferon. Differential leukocyte count and lymphocyte subset evaluation were performed every 3 days during interleukin-2 treatment. At each cycle, the presence of the following antibodies was tested: antithyroid, antinuclear, antiplatelet and antierythrocyte. Results: Fifteen patients were evaluable for response. No complete response was observed. Five patients obtained partial response (33%) and 3 stable disease (20%): 2 of them underwent surgical resection of metastases and obtained complete response. Some of our patients showed a significant increase in eosinophils, CD25+ lymphocytes and antithyroid antibodies. The association of these parameters, calculated with a 'score' system, was also related to a better clinical response. Conclusions: Eosinophils, CD25+ lymphocytes and antithyroid antibodies could have a predictive value for the efficacy of interleukin-2 and alpha-2 interferon therapy in metastatic renal cell carcinoma.

Original languageEnglish
Pages (from-to)348-352
Number of pages5
JournalTumori
Volume80
Issue number5
Publication statusPublished - 1994

Keywords

  • alpha-2 interferon
  • biologic effects
  • interleukin-2
  • metastatic renal cell carcinoma

ASJC Scopus subject areas

  • Cancer Research

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    Baiocchi, C., Landonio, G., Balzarini, G., Cacioppo, C., Calgaro, M., Ferrari, M., Gottardi, O., Majno, M., Scanzi, F., Ghislandi, E., & Brando, B. (1994). Possible correlation between some biologic effects and the clinical course in patients treated with continuous infusion of interleukin-2 plus alpha-2 interferon for metastatic renal cell carcinoma. Tumori, 80(5), 348-352.