Possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in man

F. Benfenati, P. Bernardi, P. Cortelli, M. Capelli, C. Adani, L. Calzà, L. F. Agnati

Research output: Contribution to journalArticle

Abstract

The effects of different doses of d-sulpiride (1, 6, 12 and 25 mg, i.v.) on arterial blood pressure (ABP), heart rate (HR) and prolactin (PRL), growth hormone (GH), insulin and gastrin secretions have been studied in 8 normal men. d-Sulpiride increased systolic ABP with a maximum effect rather 12 mg i.v., while it had only slight effects on diastolic ABP and HR. PRL secretion was increased by d-sulpiride in a dose-dependent way, while insulin secretion was lowered and GH secretion slightly enhanced only in a restricted range of doses (6 mg and 12 mg i.v., respectively). Gastrin secretion seemed to be unaffected by d-sulpiride at any of the tested doses. These results are discussed in view of a possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in contrast with the relatively pure antagonistic action of the levo isomer.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalNeuroscience Letters
Volume26
Issue number3
DOIs
Publication statusPublished - Nov 4 1981

    Fingerprint

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this