Possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in man

F. Benfenati, P. Bernardi, P. Cortelli, M. Capelli, C. Adani, L. Calzà, L. F. Agnati

Research output: Contribution to journalArticle

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Abstract

The effects of different doses of d-sulpiride (1, 6, 12 and 25 mg, i.v.) on arterial blood pressure (ABP), heart rate (HR) and prolactin (PRL), growth hormone (GH), insulin and gastrin secretions have been studied in 8 normal men. d-Sulpiride increased systolic ABP with a maximum effect rather 12 mg i.v., while it had only slight effects on diastolic ABP and HR. PRL secretion was increased by d-sulpiride in a dose-dependent way, while insulin secretion was lowered and GH secretion slightly enhanced only in a restricted range of doses (6 mg and 12 mg i.v., respectively). Gastrin secretion seemed to be unaffected by d-sulpiride at any of the tested doses. These results are discussed in view of a possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in contrast with the relatively pure antagonistic action of the levo isomer.

Original languageEnglish
Pages (from-to)289-295
Number of pages7
JournalNeuroscience Letters
Volume26
Issue number3
DOIs
Publication statusPublished - Nov 4 1981

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Sulpiride
Dopamine Receptors
Arterial Pressure
Gastrins
Prolactin
Growth Hormone
Heart Rate
Insulin

ASJC Scopus subject areas

  • Neuroscience(all)

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Possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in man. / Benfenati, F.; Bernardi, P.; Cortelli, P.; Capelli, M.; Adani, C.; Calzà, L.; Agnati, L. F.

In: Neuroscience Letters, Vol. 26, No. 3, 04.11.1981, p. 289-295.

Research output: Contribution to journalArticle

Benfenati, F, Bernardi, P, Cortelli, P, Capelli, M, Adani, C, Calzà, L & Agnati, LF 1981, 'Possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in man', Neuroscience Letters, vol. 26, no. 3, pp. 289-295. https://doi.org/10.1016/0304-3940(81)90147-6
Benfenati, F. ; Bernardi, P. ; Cortelli, P. ; Capelli, M. ; Adani, C. ; Calzà, L. ; Agnati, L. F. / Possible mixed agonist-antagonist activity of d-sulpiride at dopamine receptor level in man. In: Neuroscience Letters. 1981 ; Vol. 26, No. 3. pp. 289-295.
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