Possible molecular basis of cardioprotective effects of green tea

E. Pasini, A. Stephanou, C. C. Scarabelli, G. Corsetti, R. Aquilani, T. M. Scarabelli

Research output: Contribution to journalArticle

Abstract

Clinical data suggest that people who use green tea have a lower cardiovascular risk. However, the exact mechanisms of these cardioprotective effects are unknown. We know that STAT1 plays a critical role in promoting apoptotic cell death and STAT3 may antagonise STAT1 and protect cardiac myocytes from ischaemia/reperfusion (I/R) injury. More recently it has been shown that specific molecules such as epigallocatechin-3-gallate (EGCG), which is present in green tea extract (GTE), have antioxidant properties. Considering that: (i) oxygen free radicals (OFR) are produced during myocardial I/R insult and (ii) OFR are responsible for reperfusion cardiac damage, we therefore investigated whether chronic administration per os of GTE reduced I/R damage in the Langendorff perfused isolated rat heart. In addition we evaluated myocardial content of STAT1 and STAT3 and degree of apoptosis. In Sprague-Dawley isolated hearts, GTE reduced the ischaemic mechanical insult, prolonged STAT3 activation/phosphorylation and reduced STAT1 activation with consequent less cell apoptosis. These results show that chronic treatment with GTE protects the heart from I/R injury. Activation of prosurvival STAT3 over the pro-apoptotic STAT1 could be one of the molecular mechanisms involved in green tea-mediated cardiopretection.

Original languageEnglish
Pages (from-to)15-19
Number of pages5
JournalMediterranean Journal of Nutrition and Metabolism
Volume2
Issue number1
DOIs
Publication statusPublished - Apr 2009

Fingerprint

cardioprotective effect
green tea
Tea
Reperfusion Injury
ischemia
heart
extracts
Free Radicals
Reactive Oxygen Species
apoptosis
Apoptosis
oxygen
Myocardial Reperfusion
epigallocatechin
myocardial ischemia
Cardiac Myocytes
Myocardial Ischemia
cell death
phosphorylation
Cell Death

Keywords

  • Apoptosis
  • Green tea
  • Heart
  • Ischaemia
  • Reperfusion

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Food Science
  • Nutrition and Dietetics

Cite this

Possible molecular basis of cardioprotective effects of green tea. / Pasini, E.; Stephanou, A.; Scarabelli, C. C.; Corsetti, G.; Aquilani, R.; Scarabelli, T. M.

In: Mediterranean Journal of Nutrition and Metabolism, Vol. 2, No. 1, 04.2009, p. 15-19.

Research output: Contribution to journalArticle

Pasini, E, Stephanou, A, Scarabelli, CC, Corsetti, G, Aquilani, R & Scarabelli, TM 2009, 'Possible molecular basis of cardioprotective effects of green tea', Mediterranean Journal of Nutrition and Metabolism, vol. 2, no. 1, pp. 15-19. https://doi.org/10.1007/s12349-009-0036-8
Pasini, E. ; Stephanou, A. ; Scarabelli, C. C. ; Corsetti, G. ; Aquilani, R. ; Scarabelli, T. M. / Possible molecular basis of cardioprotective effects of green tea. In: Mediterranean Journal of Nutrition and Metabolism. 2009 ; Vol. 2, No. 1. pp. 15-19.
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