Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes

A. Ceriello, D. Giugliano, A. Quatraro, E. Marchi, M. Barbanti, P. Lefebvre

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In this study, total protein S (PS) immunological levels, free-PS and C4b-binding-protein (C4bBP) concentrations, and PS functional activity were investigated in insulin-dependent (type I) diabetic patients and compared with nondiabetic subjects. Mean total PS antigen concentration was not different between diabetic patients and nondiabetic subjects, whereas free-PS levels and PS functional activity were significantly reduced in diabetic patients. C4bBP was increased in diabetic patients and correlated with HbA1 levels. This study shows that type I diabetic patients have depressed free PS and PS activity despite the presence of normal total PS concentration and suggests that this phenomenon is probably linked to the increase of circulating C4bBP.

Original languageEnglish
Pages (from-to)447-449
Number of pages3
JournalDiabetes
Volume39
Issue number4
Publication statusPublished - 1990

Fingerprint

Complement C4b-Binding Protein
Protein S
Type 1 Diabetes Mellitus
Acquired Protein S Deficiency
Glycosylated Hemoglobin A
Insulin
Antigens

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Internal Medicine

Cite this

Ceriello, A., Giugliano, D., Quatraro, A., Marchi, E., Barbanti, M., & Lefebvre, P. (1990). Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes. Diabetes, 39(4), 447-449.

Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes. / Ceriello, A.; Giugliano, D.; Quatraro, A.; Marchi, E.; Barbanti, M.; Lefebvre, P.

In: Diabetes, Vol. 39, No. 4, 1990, p. 447-449.

Research output: Contribution to journalArticle

Ceriello, A, Giugliano, D, Quatraro, A, Marchi, E, Barbanti, M & Lefebvre, P 1990, 'Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes', Diabetes, vol. 39, no. 4, pp. 447-449.
Ceriello A, Giugliano D, Quatraro A, Marchi E, Barbanti M, Lefebvre P. Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes. Diabetes. 1990;39(4):447-449.
Ceriello, A. ; Giugliano, D. ; Quatraro, A. ; Marchi, E. ; Barbanti, M. ; Lefebvre, P. / Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes. In: Diabetes. 1990 ; Vol. 39, No. 4. pp. 447-449.
@article{673801079a6b474abb2a80c4542867e2,
title = "Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes",
abstract = "In this study, total protein S (PS) immunological levels, free-PS and C4b-binding-protein (C4bBP) concentrations, and PS functional activity were investigated in insulin-dependent (type I) diabetic patients and compared with nondiabetic subjects. Mean total PS antigen concentration was not different between diabetic patients and nondiabetic subjects, whereas free-PS levels and PS functional activity were significantly reduced in diabetic patients. C4bBP was increased in diabetic patients and correlated with HbA1 levels. This study shows that type I diabetic patients have depressed free PS and PS activity despite the presence of normal total PS concentration and suggests that this phenomenon is probably linked to the increase of circulating C4bBP.",
author = "A. Ceriello and D. Giugliano and A. Quatraro and E. Marchi and M. Barbanti and P. Lefebvre",
year = "1990",
language = "English",
volume = "39",
pages = "447--449",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association Inc.",
number = "4",

}

TY - JOUR

T1 - Possible role for increased C4b-binding-protein level in acquired protein S deficiency in type I diabetes

AU - Ceriello, A.

AU - Giugliano, D.

AU - Quatraro, A.

AU - Marchi, E.

AU - Barbanti, M.

AU - Lefebvre, P.

PY - 1990

Y1 - 1990

N2 - In this study, total protein S (PS) immunological levels, free-PS and C4b-binding-protein (C4bBP) concentrations, and PS functional activity were investigated in insulin-dependent (type I) diabetic patients and compared with nondiabetic subjects. Mean total PS antigen concentration was not different between diabetic patients and nondiabetic subjects, whereas free-PS levels and PS functional activity were significantly reduced in diabetic patients. C4bBP was increased in diabetic patients and correlated with HbA1 levels. This study shows that type I diabetic patients have depressed free PS and PS activity despite the presence of normal total PS concentration and suggests that this phenomenon is probably linked to the increase of circulating C4bBP.

AB - In this study, total protein S (PS) immunological levels, free-PS and C4b-binding-protein (C4bBP) concentrations, and PS functional activity were investigated in insulin-dependent (type I) diabetic patients and compared with nondiabetic subjects. Mean total PS antigen concentration was not different between diabetic patients and nondiabetic subjects, whereas free-PS levels and PS functional activity were significantly reduced in diabetic patients. C4bBP was increased in diabetic patients and correlated with HbA1 levels. This study shows that type I diabetic patients have depressed free PS and PS activity despite the presence of normal total PS concentration and suggests that this phenomenon is probably linked to the increase of circulating C4bBP.

UR - http://www.scopus.com/inward/record.url?scp=0025317676&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025317676&partnerID=8YFLogxK

M3 - Article

C2 - 2138576

AN - SCOPUS:0025317676

VL - 39

SP - 447

EP - 449

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 4

ER -