Possible role of chest ultrasonography for the evaluation of peripheral fibrotic pulmonary changes in patients affected by idiopathic pulmonary fibrosis-pilot case series

Andrea Smargiassi, Riccardo Inchingolo, Lucio Calandriello, Francesco Lombardi, Angelo Calabrese, Matteo Siciliano, Anna Rita Larici, Libertario Demi, Luca Richeldi, Gino Soldati

Research output: Contribution to journalArticlepeer-review

Abstract

Lung ultrasonography (LUS) provides an estimation of peripheral airspace (PAS) geometry of the lung. Altered PAS produces sonographic interstitial syndrome (SIS). Idiopathic pulmonary fibrosis (IPF) involves peripheral lung with altered PAS. The aim of the study is to correlate echographic patterns with peripheral fibrotic changes on high-resolution Chest CT scan (HRCT). Patients underwent LUS and HRCT on the same date. Four LUS patterns were described: (1) near normal; (2) SIS with predominance of reverberant artifacts; (3) SIS with vertical predominance; (4) white lung. Four HRCT grades of peripheral fibrotic infiltrates were reported: grade 1 mild; grade 2 moderate; grade 3 severe; grade 4 massive or honeycomb. LUS pattern 1 was indicative of mild to moderate fibrotic alterations in 100% of cases. LUS pattern 2 matched with HRCT grade 2 in 24 out of 30 cases (77%). Huge discordance in four cases because of large honeycomb cysts. LUS pattern 3 was indicative of severe to massive alterations in 100% of cases. LUS pattern 4 showed a heterogeneous distribution of HRCT grades, severe changes, and ground glass opacities (GGO). This preliminary work demonstrates some level of agreement between LUS patterns and HRCT grades. Limitations and methodological issues have been shown to support subsequent studies of agreement.

Original languageEnglish
Article number1617
JournalApplied Sciences (Switzerland)
Volume10
Issue number5
DOIs
Publication statusPublished - Mar 1 2020

Keywords

  • Idiopathic pulmonary fibrosis
  • Lung ultrasound
  • Sonographic interstitial syndrome

ASJC Scopus subject areas

  • Materials Science(all)
  • Instrumentation
  • Engineering(all)
  • Process Chemistry and Technology
  • Computer Science Applications
  • Fluid Flow and Transfer Processes

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