Possible role of cytokines in the pathogenesis of non-organ specific autoimmunity

S. Zupo, M. Dono, L. Azzoni, N. Chiorazzi, M. Ferrarini

Research output: Contribution to journalArticlepeer-review


This paper describes the experiments conducted in our laboratory on the mode of activation of CD5+ B cells. The data show that these cells are stimulated in a manner that is less dependent of T cell help as compared to CD5- cells and define IL-2 as the major growth and differentiation factor for CD5+ cells. These data are discussed in the light of the supposed function of CD5+ cells that seem represented by the capacity to release polyspecific antibodies reacting with a multiplicity of antigens from various pathogens. These antibodies, also called natural antibodies, probably represent one of the first lines of defense against invading microrganisms.

Original languageEnglish
Pages (from-to)149-154
Number of pages6
JournalInternational Journal of Immunopathology and Pharmacology
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Pharmacology


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