Possible role of HLA B8 antigen as a genetic marker of autoimmune thrombocytopenia in a patient with myasthenia gravis

G. Remuzzi, R. Misiani, M. Livio, A. dall'Olio, M. B. Donati, G. de Gaetano

Research output: Contribution to journalArticlepeer-review

Abstract

Very recently, Goebel et al. reported a highly significant association between HLA-B8 antigen and autoimmune thrombocytopenic purpura (ATP). This antigen was reported in ATP patients at least as frequently (70%) as positive tests for antiplatele antibody (65%). HLA-B8 might therefore be considered as a marker of specific immuneresponse genes which could selectively code for antiplatelet antibody activity. Goebel et al. suggested that individuals who have this specific phenotype run a higher risk of developing the disease if they are exposed to additionalcausal factors likely to trigger ATP. The presented case report strongly supports this suggstion.

Original languageEnglish
Pages (from-to)593-594
Number of pages2
JournalThrombosis and Haemostasis
Volume38
Issue number2
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Hematology

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