Possible role of plasma neurotensin on growth hormone regulation in neonates

Mauro Bozzola, Agnes Ntodou-Thome, Gianni Bona, Michele Autelli, Maria Luisa Magnani, Giorgio Radetti, Rose Marie Schimpff

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To evaluate secretion of plasma neurotensin (NT) which could be involved as a peripheral signal in growth hormone (GH) regulation, NT release was measured during early postnatal life, a period of striking changes in GH secretion. Methods: Blood samples were collected from 19 normal full-term neonates on day 5 and at 3 months of age to evaluate plasma NT concentrations by radioimmunoassay, serum growth hormone (GH) levels using an immunofluorometric assay, and serum insulin-like growth factor-I (IGF-I) values by radioimmunoassay. Results: Five day-old neonates showed significantly higher (p

Original languageEnglish
Pages (from-to)607-613
Number of pages7
JournalJournal of Pediatric Endocrinology and Metabolism
Volume11
Issue number5
Publication statusPublished - 1998

Keywords

  • Growth hormone
  • Infants
  • Insulin-like growth factor-I
  • Neurotensin

ASJC Scopus subject areas

  • Endocrinology
  • Pediatrics, Perinatology, and Child Health

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