Possible role of transforming growth factor-β in relapsing-remitting multiple sclerosis

P. B. Carrieri, V. Provitera, R. Bruno, M. Perrella, G. Tartaglia, A. Busto, O. Perrella

Research output: Contribution to journalArticlepeer-review

Abstract

Cerebrospinal fluid (CSF) and serum levels of transforming growth factor (TGF)-β and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in ten patients with definite multiple sclerosis (MS) of the relapsing-remitting type. CSF TGF-β levels of MS patients in remission were significantly (p <0.01) higher than of MS patients in active phase, and there was a significant inverse correlation (p <0.05) between TGF-β and sICAM-1 levels in the CSF of patients in both remitting and relapsing type. This is consistent with a possible down-regulation of TGF-β on ICAM-1 expression and suggests a possible synthesis in the central nervous system of TGF-β.

Original languageEnglish
Pages (from-to)599-600
Number of pages2
JournalNeurological Research
Volume19
Issue number6
Publication statusPublished - 1997

Keywords

  • Cerebrospinal fluid
  • Multiple sclerosis
  • SICAM-1
  • TGF-β

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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