Abstract
6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.
| Original language | English |
|---|---|
| Pages (from-to) | 275-279 |
| Number of pages | 5 |
| Journal | European Journal of Pharmacology |
| Volume | 41 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Feb 7 1977 |
Keywords
- (+)-Amphetamine 5,6-Dihydroxytryptamine
- 6-Hydroxydopamine
- Catecholamine neurons
- Drug localization
- Pentobarbital
- Specific binding
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology
Fingerprint Dive into the research topics of 'Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem'. Together they form a unique fingerprint.
Cite this
Jori, A., Caccia, S., & Garattini, S. (1977). Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem. European Journal of Pharmacology, 41(3), 275-279. https://doi.org/10.1016/0014-2999(77)90320-X