Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem

Armanda Jori; Silvio Caccia; Silvio Garattini

doi:10.1016/0014-2999(77)90320-X

Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem

Armanda Jori, Silvio Caccia, Silvio Garattini

Istituto di Ricerche Farmacologiche "Mario Negri"

Research output: Contribution to journal › Article › peer-review

Abstract

6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.

Original language	English
Pages (from-to)	275-279
Number of pages	5
Journal	European Journal of Pharmacology
Volume	41
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(77)90320-X
Publication status	Published - Feb 7 1977

Keywords

(+)-Amphetamine 5,6-Dihydroxytryptamine
6-Hydroxydopamine
Catecholamine neurons
Drug localization
Pentobarbital
Specific binding

ASJC Scopus subject areas

Cellular and Molecular Neuroscience
Pharmacology

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title = "Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem",

abstract = "6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.",

keywords = "(+)-Amphetamine 5,6-Dihydroxytryptamine, 6-Hydroxydopamine, Catecholamine neurons, Drug localization, Pentobarbital, Specific binding",

author = "Armanda Jori and Silvio Caccia and Silvio Garattini",

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T1 - Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem

AU - Jori, Armanda

AU - Caccia, Silvio

AU - Garattini, Silvio

PY - 1977/2/7

Y1 - 1977/2/7

N2 - 6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.

AB - 6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.

KW - (+)-Amphetamine 5,6-Dihydroxytryptamine

KW - 6-Hydroxydopamine

KW - Catecholamine neurons

KW - Drug localization

KW - Pentobarbital

KW - Specific binding

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

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ER -

Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem

Abstract

Keywords

ASJC Scopus subject areas

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