Possible storage of (+)-amphetamine in catecholaminergic terminals of the striatum and brainstem

Armanda Jori, Silvio Caccia, Silvio Garattini

Research output: Contribution to journalArticle

Abstract

6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.

Original languageEnglish
Pages (from-to)275-279
Number of pages5
JournalEuropean Journal of Pharmacology
Volume41
Issue number3
DOIs
Publication statusPublished - Feb 7 1977

Keywords

  • (+)-Amphetamine 5,6-Dihydroxytryptamine
  • 6-Hydroxydopamine
  • Catecholamine neurons
  • Drug localization
  • Pentobarbital
  • Specific binding

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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