Abstract
6-Hydroxydopamine, given intraventricularly, did not affect the high concentrations of (+)-amphetamine present in the rat striatum and brainstem 1 h after its administration but considerably reduced the small amounts of (+)-amphetamine remaining after 5 h. In contrast, 5,6-dihydroxytryptamine did not modify the (+)-amphetamine concentrations at the times tested. These findings suggest that (+)-amphetamine might be stored in the catecholaminergic but not in serotonergic central terminals.
Original language | English |
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Pages (from-to) | 275-279 |
Number of pages | 5 |
Journal | European Journal of Pharmacology |
Volume | 41 |
Issue number | 3 |
DOIs | |
Publication status | Published - Feb 7 1977 |
Keywords
- (+)-Amphetamine 5,6-Dihydroxytryptamine
- 6-Hydroxydopamine
- Catecholamine neurons
- Drug localization
- Pentobarbital
- Specific binding
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
- Pharmacology