Objective: To evaluate the prognostic role of both interim fluorine-18 fludeoxyglucose positron emission tomography (i-18F-FDG-PET) and end-of-chemotherapy fluorine-18 fludeoxyglucose positron emission tomography (eoc-18F-FDG-PET) in patients with early-stage Hodgkin lymphoma (HL). Methods: We screened 257 patients with early-stage HL treated with combined modality therapy between March 2003 and July 2011. All were staged using fluorine-18 fludeoxyglucose positron emission tomography (18F-FDGPET) before chemotherapy and after two doxorubicin, bleomycin, vinblastine and dacarbazine cycles (i-18F-FDGPET); 165 patients were also evaluated by 18F-FDG-PET at the end of chemotherapy (eoc-18F-FDG-PET). Results: After revision, 85% of patients were negative for i-18F-FDG-PET and 15% were positive. After eoc-18F-FDGPET revision, 23 patients had a positive scan. The median follow-up was 56 months. The 5-year overall survival (OS) and progression-free survival (PFS) for the whole cohort were 97.5% and 95.6%, respectively. For i-18F-FDGPET-negative and i-18F-FDG-PET-positive patients, the 5-year PFS rates were 98% and 84%, respectively; for eoc-18F-FDG-PET-negative and eoc-18F-FDG-PET-positive patients, the 5-year PFS rates were 97% and 78%, respectively. Combining the i-18F-FDG-PET and eoc-18F-FDGPET results, the 5-year PFS were 97%, 100% and 82% in negative/negative, positive/negative and positive/positive groups, respectively. The 5-year OS rates were 98% and 83% in eoc-18F-FDG-PET-negative and eoc-18F-FDG-PET-positive patients, respectively; the 5-year OS was 98%, 100% and 83% in negative/negative, positive/negative and positive/ positive groups, respectively. Conclusion: This study provides additional information on the prognostic role of i-18F-FDG-PET and eoc-18FFDG-PET in early-stage HL. As data are accumulating and the clinical scenario is rapidly evolving, we might need to rethink the use of 18F-FDG-PET as a prognostic marker for early-stage HL in the near future.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging