Post-coital contraception: An overview of published studies

Monica Fasoli, Fabio Parazzini, Gabriela Cecchetti, Carlo La Vecchia

Research output: Contribution to journalArticle


Information from published studies testing the effect of hormonal and mechanical interceptive methods in post-coital contraception was pooled with the aim of assessing the efficacy of various regimens. The pooled failure rates were 0.6% ( 19 3168 based on four studies) for high-dosage ethinylestradiol, 1.1% ( 11 975, based on two studies) for other high-dose estrogens, 1.8% ( 69 3802 based on 11 studies) for combined estro-progestin preparations, 2.0% ( 20 998 based on three studies) for danazol and 0.1% ( 1 879 based on nine studies) for intra-uterine devices (IUD). Although this overview has several limitations in terms of over-representation of optimistic results in the literature or absence of direct comparison between treatments in several studies, it suggests that IUD and high-dose ethinylestradiol are more efficacious forms of post-coital contraception than danazol or combined contraceptives.

Original languageEnglish
Pages (from-to)459-468
Number of pages10
Issue number4
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynaecology

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