Post-irradiation malignant mesothelioma

Alberto Cavazza, Lois B. Travis, William D. Travis, James T. Wolfe, May L. Foo, Delmar J. Gillespie, Noel Weidner, Thomas V. Colby

Research output: Contribution to journalArticle

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Abstract

BACKGROUND. Approximately 30 patients with malignant mesothelioma following radiotherapy have been described. Population-based studies of this occurrence have not been reported. METHODS. Patients with malignant mesothelioma of the pleura were collected. All of the patients had a prior cancer and had received radiotherapy to the region in which the malignant mesothelioma developed. Data from the National Cancer Institute's Surveillance, Epidemiology and End Results Program and the Connecticut Tumor Registry were evaluated for cases of malignant mesothelioma of the pleura occurring in patients with a previous cancer. The literature on post- irradiation malignant mesotheliomas was reviewed. RESULTS. Eight patients (4 men, 4 women) with malignant mesothelioma occurring in sites of radiotherapy for a prior tumor were identified. The mean age at diagnosis of mesothelioma was 45 years (range: 22-78 years), and the average interval between radiotherapy and the mesothelioma was 21 years (range: 11-29 years). Three of the patients had also received chemotherapy. Histologically, the mesotheliomas were epithelial in five cases, biphasic in one, and sarcomatous in one. One hundred forty-two patients were identified in the epidemiologic survey. The majority were men (89%), with a median age for all patients of 68.5 years (range: 35-86 years) and a median latency between first cancer and mesothelioma of 4.3 years (range: 2 months-29.9 years). CONCLUSIONS. Mesotheliomas rarely develop as second malignant neoplasms. Within a large, population-based survey of patients with cancer, temporal patterns and demographic features of most second primary mesotheliomas were similar to asbestos-related tumors, although the late effects of cancer treatment might have contributed to the occurrence of cancer ill some patients.

Original languageEnglish
Pages (from-to)1379-1385
Number of pages7
JournalCancer
Volume77
Issue number7
DOIs
Publication statusPublished - Apr 1 1996

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Mesothelioma
Neoplasms
Radiotherapy
Pleura
Malignant Mesothelioma
SEER Program
Second Primary Neoplasms
National Cancer Institute (U.S.)
Asbestos
Population
Registries
Demography
Drug Therapy

Keywords

  • breast carcinoma
  • Hodgkin's disease
  • mesothelioma
  • radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Cavazza, A., Travis, L. B., Travis, W. D., Wolfe, J. T., Foo, M. L., Gillespie, D. J., ... Colby, T. V. (1996). Post-irradiation malignant mesothelioma. Cancer, 77(7), 1379-1385. https://doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1379::AID-CNCR24>3.0.CO;2-Y

Post-irradiation malignant mesothelioma. / Cavazza, Alberto; Travis, Lois B.; Travis, William D.; Wolfe, James T.; Foo, May L.; Gillespie, Delmar J.; Weidner, Noel; Colby, Thomas V.

In: Cancer, Vol. 77, No. 7, 01.04.1996, p. 1379-1385.

Research output: Contribution to journalArticle

Cavazza, A, Travis, LB, Travis, WD, Wolfe, JT, Foo, ML, Gillespie, DJ, Weidner, N & Colby, TV 1996, 'Post-irradiation malignant mesothelioma', Cancer, vol. 77, no. 7, pp. 1379-1385. https://doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1379::AID-CNCR24>3.0.CO;2-Y
Cavazza A, Travis LB, Travis WD, Wolfe JT, Foo ML, Gillespie DJ et al. Post-irradiation malignant mesothelioma. Cancer. 1996 Apr 1;77(7):1379-1385. https://doi.org/10.1002/(SICI)1097-0142(19960401)77:7<1379::AID-CNCR24>3.0.CO;2-Y
Cavazza, Alberto ; Travis, Lois B. ; Travis, William D. ; Wolfe, James T. ; Foo, May L. ; Gillespie, Delmar J. ; Weidner, Noel ; Colby, Thomas V. / Post-irradiation malignant mesothelioma. In: Cancer. 1996 ; Vol. 77, No. 7. pp. 1379-1385.
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abstract = "BACKGROUND. Approximately 30 patients with malignant mesothelioma following radiotherapy have been described. Population-based studies of this occurrence have not been reported. METHODS. Patients with malignant mesothelioma of the pleura were collected. All of the patients had a prior cancer and had received radiotherapy to the region in which the malignant mesothelioma developed. Data from the National Cancer Institute's Surveillance, Epidemiology and End Results Program and the Connecticut Tumor Registry were evaluated for cases of malignant mesothelioma of the pleura occurring in patients with a previous cancer. The literature on post- irradiation malignant mesotheliomas was reviewed. RESULTS. Eight patients (4 men, 4 women) with malignant mesothelioma occurring in sites of radiotherapy for a prior tumor were identified. The mean age at diagnosis of mesothelioma was 45 years (range: 22-78 years), and the average interval between radiotherapy and the mesothelioma was 21 years (range: 11-29 years). Three of the patients had also received chemotherapy. Histologically, the mesotheliomas were epithelial in five cases, biphasic in one, and sarcomatous in one. One hundred forty-two patients were identified in the epidemiologic survey. The majority were men (89{\%}), with a median age for all patients of 68.5 years (range: 35-86 years) and a median latency between first cancer and mesothelioma of 4.3 years (range: 2 months-29.9 years). CONCLUSIONS. Mesotheliomas rarely develop as second malignant neoplasms. Within a large, population-based survey of patients with cancer, temporal patterns and demographic features of most second primary mesotheliomas were similar to asbestos-related tumors, although the late effects of cancer treatment might have contributed to the occurrence of cancer ill some patients.",
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AU - Cavazza, Alberto

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AU - Weidner, Noel

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N2 - BACKGROUND. Approximately 30 patients with malignant mesothelioma following radiotherapy have been described. Population-based studies of this occurrence have not been reported. METHODS. Patients with malignant mesothelioma of the pleura were collected. All of the patients had a prior cancer and had received radiotherapy to the region in which the malignant mesothelioma developed. Data from the National Cancer Institute's Surveillance, Epidemiology and End Results Program and the Connecticut Tumor Registry were evaluated for cases of malignant mesothelioma of the pleura occurring in patients with a previous cancer. The literature on post- irradiation malignant mesotheliomas was reviewed. RESULTS. Eight patients (4 men, 4 women) with malignant mesothelioma occurring in sites of radiotherapy for a prior tumor were identified. The mean age at diagnosis of mesothelioma was 45 years (range: 22-78 years), and the average interval between radiotherapy and the mesothelioma was 21 years (range: 11-29 years). Three of the patients had also received chemotherapy. Histologically, the mesotheliomas were epithelial in five cases, biphasic in one, and sarcomatous in one. One hundred forty-two patients were identified in the epidemiologic survey. The majority were men (89%), with a median age for all patients of 68.5 years (range: 35-86 years) and a median latency between first cancer and mesothelioma of 4.3 years (range: 2 months-29.9 years). CONCLUSIONS. Mesotheliomas rarely develop as second malignant neoplasms. Within a large, population-based survey of patients with cancer, temporal patterns and demographic features of most second primary mesotheliomas were similar to asbestos-related tumors, although the late effects of cancer treatment might have contributed to the occurrence of cancer ill some patients.

AB - BACKGROUND. Approximately 30 patients with malignant mesothelioma following radiotherapy have been described. Population-based studies of this occurrence have not been reported. METHODS. Patients with malignant mesothelioma of the pleura were collected. All of the patients had a prior cancer and had received radiotherapy to the region in which the malignant mesothelioma developed. Data from the National Cancer Institute's Surveillance, Epidemiology and End Results Program and the Connecticut Tumor Registry were evaluated for cases of malignant mesothelioma of the pleura occurring in patients with a previous cancer. The literature on post- irradiation malignant mesotheliomas was reviewed. RESULTS. Eight patients (4 men, 4 women) with malignant mesothelioma occurring in sites of radiotherapy for a prior tumor were identified. The mean age at diagnosis of mesothelioma was 45 years (range: 22-78 years), and the average interval between radiotherapy and the mesothelioma was 21 years (range: 11-29 years). Three of the patients had also received chemotherapy. Histologically, the mesotheliomas were epithelial in five cases, biphasic in one, and sarcomatous in one. One hundred forty-two patients were identified in the epidemiologic survey. The majority were men (89%), with a median age for all patients of 68.5 years (range: 35-86 years) and a median latency between first cancer and mesothelioma of 4.3 years (range: 2 months-29.9 years). CONCLUSIONS. Mesotheliomas rarely develop as second malignant neoplasms. Within a large, population-based survey of patients with cancer, temporal patterns and demographic features of most second primary mesotheliomas were similar to asbestos-related tumors, although the late effects of cancer treatment might have contributed to the occurrence of cancer ill some patients.

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