TY - JOUR
T1 - Post-ischemic brain damage
T2 - NF-κB dimer heterogeneity as a molecular determinant of neuron vulnerability
AU - Pizzi, Marina
AU - Sarnico, Ilenia
AU - Lanzillotta, Annamaria
AU - Battistin, Leontino
AU - Spano, PierFranco
PY - 2009/1
Y1 - 2009/1
N2 - Nuclear factor-kappaB (NF-κB) has been proposed to serve a dual function as a regulator of neuron survival in pathological conditions associated with neurodegeneration. NF-κB is a transcription family of factors comprising five different proteins, namely p50, RelA/p65, c-Rel, RelB and p52, which can combine differently to form active dimers in response to external stimuli. Recent research shows that diverse NF-κB dimers lead to cell death or cell survival in neurons exposed to ischemic injury. While the p50/p65 dimer participates in the pathogenesis of post-ischemic injury by inducing pro-apoptotic gene expression, c-Rel-containing dimers increase neuron resistance to ischemia by inducing anti-apoptotic gene transcription. We present, in this report, the latest findings and consider the therapeutic potential of targeting different NF-κB dimers to limit ischemia-associated neurodegeneration.
AB - Nuclear factor-kappaB (NF-κB) has been proposed to serve a dual function as a regulator of neuron survival in pathological conditions associated with neurodegeneration. NF-κB is a transcription family of factors comprising five different proteins, namely p50, RelA/p65, c-Rel, RelB and p52, which can combine differently to form active dimers in response to external stimuli. Recent research shows that diverse NF-κB dimers lead to cell death or cell survival in neurons exposed to ischemic injury. While the p50/p65 dimer participates in the pathogenesis of post-ischemic injury by inducing pro-apoptotic gene expression, c-Rel-containing dimers increase neuron resistance to ischemia by inducing anti-apoptotic gene transcription. We present, in this report, the latest findings and consider the therapeutic potential of targeting different NF-κB dimers to limit ischemia-associated neurodegeneration.
KW - Bcl-xL
KW - Bim
KW - Brain ischemia
KW - c-Rel
KW - Cell death
KW - Leptin
KW - Neurodegeneration
KW - Nuclear factor-kappaB
KW - Oxygen glucose deprivation
KW - p65
UR - http://www.scopus.com/inward/record.url?scp=57649146521&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57649146521&partnerID=8YFLogxK
U2 - 10.1111/j.1742-4658.2008.06767.x
DO - 10.1111/j.1742-4658.2008.06767.x
M3 - Article
C2 - 19087197
AN - SCOPUS:57649146521
VL - 276
SP - 27
EP - 35
JO - FEBS Journal
JF - FEBS Journal
SN - 1742-464X
IS - 1
ER -