Post-ischemic treatment with cannabidiol prevents electroencephalographic flattening, hyperlocomotion and neuronal injury in gerbils

Daniela Braida, Simona Pegorini, Maria Vittoria Arcidiacono, Gian Giacomo Consalez, Laura Croci, Mariaelvina Sala

Research output: Contribution to journalArticle

Abstract

The potential activity of cannabidiol, a non-psychoactive constituent of marijuana, in preventing damage caused by cerebral ischemia was studied. Cannabidiol (1.25-20 mg/kg) was given 5 min after 10 min bilateral carotid occlusion in freely-moving awake gerbils. Seven days after ischemia, it antagonized the electroencephalographic flattening of total spectral power, with a dose-dependent bell-shaped curve; the neuroprotective effect was greatest with 5 mg/kg. One day after ischemia cannabidiol completely antagonized ischemia-induced hyperlocomotion, at all doses. Rectal temperature did not change during the first hour after occlusion. Histological examination showed complete survival of CA1 neurons in cannabidiol-treated gerbils. These findings suggest a potential therapeutic role of cannabidiol in cerebral ischemia, though the clear mechanism of action remains to be elucidated.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalNeuroscience Letters
Volume346
Issue number1-2
DOIs
Publication statusPublished - Jul 31 2003

Keywords

  • Global ischemia
  • Motor activity
  • Natural cannabinoid
  • Neuroprotection
  • Temperature

ASJC Scopus subject areas

  • Neuroscience(all)

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